通过大鼠胎儿胸腺移植重建T细胞功能后，裸鼠发生多器官定位的自身免疫性疾病。
Development of multiple organ-localized autoimmune diseases in nude mice after reconstitution of T cell function by rat fetal thymus graft.
作者信息
Taguchi O, Takahashi T, Seto M, Namikawa R, Matsuyama M, Nishizuka Y
出版信息
J Exp Med. 1986 Jul 1;164(1):60-71. doi: 10.1084/jem.164.1.60.
Restoration of T cell function of athymic BALB/c nu/nu mice was investigated after transplantation of xenogeneic thymic rudiments from 15-d-old embryonic rats into kidney subcapsule. The rudiments developed well and formed a proper thymus structure composed of donor epithelia and host lymphocytes. Examination of antibody responses to SRBC revealed that approximately half the normal number of indirect PFCs were observed. Skin grafts from syngeneic BALB/c mice and thymic donor rat strains were accepted, whereas those from allogeneic mice and the rats of other than donor strains were vigorously rejected. Thymus-grafted nude mice under a conventional environment survived without any evident infectious diseases. Histological and immunofluorescence studies, however, showed a high incidence of multiple organ-localized autoimmune diseases in thyroid, salivary gland, stomach, adrenal, prostate, ovary, and testis in mice that produced the corresponding autoantibodies. These results together suggested that rat thymic grafts reconstituted T cell functions of nu/nu mice to a considerable degree, but that organ-localized autoimmune diseases developed, probably because certain auto-antigens of the recipients were recognized by the newly reconstituted host immunity.
将15日龄胚胎大鼠的异种胸腺原基移植到无胸腺BALB/c裸鼠的肾被膜下后，对其T细胞功能的恢复情况进行了研究。胸腺原基发育良好，形成了由供体上皮和宿主淋巴细胞组成的正常胸腺结构。对SRBC的抗体反应检测显示，间接PFC的数量约为正常数量的一半。同基因BALB/c小鼠和胸腺供体大鼠品系的皮肤移植被接受，而异基因小鼠和供体品系以外的大鼠的皮肤移植则被强烈排斥。在传统环境下移植胸腺的裸鼠存活下来，没有任何明显的传染病。然而，组织学和免疫荧光研究表明，产生相应自身抗体的小鼠中，甲状腺、唾液腺、胃、肾上腺、前列腺、卵巢和睾丸等多器官局部自身免疫性疾病的发生率很高。这些结果共同表明，大鼠胸腺移植在相当程度上重建了裸鼠的T细胞功能，但出现了器官局部自身免疫性疾病，可能是因为新重建的宿主免疫识别了受体的某些自身抗原。
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