Sato Kazuhiko, Yazawa Yukako, Igasaki Shota, Saito Takuya, Kawabata Yuichi, Nakashima Ichiro
Department of Neurology, Tohoku Medical and Pharmaceutical University Hospital, 1-15-1 Fukumuro, Miyagino-ku, Sendai, Miyagi, 983-8536, Japan; Department of Stroke Neurology, Kohnan Hospital, 4-20-1 Nagamachi-minami, Taihaku-ku, Sendai, Miyagi, 982-8523, Japan.
Department of Stroke Neurology, Kohnan Hospital, 4-20-1 Nagamachi-minami, Taihaku-ku, Sendai, Miyagi, 982-8523, Japan.
J Stroke Cerebrovasc Dis. 2022 May;31(5):106399. doi: 10.1016/j.jstrokecerebrovasdis.2022.106399. Epub 2022 Feb 25.
To describe the case of an ischemic stroke patient with Klippel-Feil syndrome who developed multiple aneurysms and discuss the mechanism of aneurysm development.
A 44-year-old man presented with dizziness, left hemiparesis, and left-sided numbness and was admitted to our department. He developed multiple aneurysms at the bilateral vertebral artery (VA) and bilateral internal carotid artery.
We diagnosed the etiology of his brain infarction as an embolic stroke caused by left VA dissection or the large thrombosed aneurysm. Furthermore, we considered that arterial dissection or Hox gene mutation was associated with the development of multiple aneurysms.
While previous reports have described single aneurysm, this is the first report of multiple aneurysms associated with Klippel-Feil syndrome.
描述一名患有克利佩尔-费尔综合征的缺血性中风患者发生多发性动脉瘤的病例，并探讨动脉瘤形成的机制。
一名44岁男性因头晕、左侧偏瘫和左侧麻木入院。他在双侧椎动脉（VA）和双侧颈内动脉出现多发性动脉瘤。
我们将其脑梗死的病因诊断为左侧椎动脉夹层或大型血栓形成性动脉瘤所致的栓塞性中风。此外，我们认为动脉夹层或Hox基因突变与多发性动脉瘤的发生有关。
虽然既往报道描述的是单个动脉瘤，但这是首例与克利佩尔-费尔综合征相关的多发性动脉瘤报道。
