Timmis D P, Aragon S B, Van Sickels J E, Aufdemorte T B
J Oral Maxillofac Surg. 1986 Jul;44(7):541-54. doi: 10.1016/s0278-2391(86)80094-5.
Young adult, white New Zealand rabbits underwent either sham surgical procedures or discectomy. In the animals that underwent discectomy, either reinforced silicone or polytetrafluoroethylene-aluminum oxide (PTFE-Al2O3) implants were placed in the glenoid fossa. During gross sectioning, the silicone implants could be easily displaced from the specimen, while the PTFE-Al2O3 implants were firmly anchored. Histologically, fragmentation of the implants was seen in the silicone group; 21.4% of the implants placed were torn. Foreign body giant cell reactions reached a peak after eight weeks. Associated fibrosis and foreign body giant cell reactions were seen, resulting in a thickened capsule and resorption of the condyle and articular fossa. In the PTFE-Al2O3 group there was marked osteoclastic activity, with resorption and severe degenerative changes in both the condyle and glenoid fossa. The foreign body giant cell reaction was severe at all time intervals and increased with time. Tearing of the implant was observed in 46.2% of the joints. These results indicate a need for further evaluation of these materials as disc replacements in humans.
年轻成年的新西兰白兔接受了假手术或椎间盘切除术。在接受椎间盘切除术的动物中，将增强硅胶或聚四氟乙烯 - 氧化铝（PTFE - Al2O3）植入物置于关节盂窝。在大体切片过程中，硅胶植入物很容易从标本中移位，而PTFE - Al2O3植入物则牢固地固定。组织学上，硅胶组可见植入物破碎；所植入的植入物中有21.4%被撕裂。异物巨细胞反应在八周后达到峰值。可见相关的纤维化和异物巨细胞反应，导致关节囊增厚以及髁突和关节窝吸收。在PTFE - Al2O3组中，有明显的破骨细胞活性，髁突和关节盂窝均有吸收和严重的退行性改变。异物巨细胞反应在所有时间间隔均很严重，并随时间增加。在46.2%的关节中观察到植入物撕裂。这些结果表明需要进一步评估这些材料作为人类椎间盘替代物的可能性。
