Department of Hematology and Medical Oncology, Shinshu University School of Medicine, Japan.
Department of Surgery, Division of Gastroenterological, Hepato-Biliary-Pancreatic, Transplantation and Pediatric Surgery, Shinshu University School of Medicine, Japan.
Intern Med. 2022;61(5):709-713. doi: 10.2169/internalmedicine.8223-21. Epub 2022 Mar 1.
A 67-year-old man with a history of esophageal cancer resection was referred to our hospital because of nausea and appetite loss. Laboratory findings showed severe hyponatremia and were compatible with syndrome of inappropriate antidiuretic hormone (SIADH) secretion. Chest computed tomography (CT) revealed a nodule measuring 13 mm in the lower lobe of the right lung. Right thoracotomy was performed, and the histopathological diagnosis was small-cell lung cancer (T1bN0M0; Stage 1b). Although SIADH is frequently associated with small-cell lung cancer, it is extremely rare as the initial clinical feature in stage I small-cell lung cancer.
一位 67 岁男性，有食管癌切除术病史，因恶心和食欲不振就诊于我院。实验室检查发现严重低钠血症，符合抗利尿激素分泌不当综合征（SIADH）的表现。胸部计算机断层扫描（CT）显示右下肺叶有一个 13 毫米的结节。行右开胸术，组织病理学诊断为小细胞肺癌（T1bN0M0；I 期 b 型）。尽管 SIADH 常与小细胞肺癌相关，但在 I 期小细胞肺癌中，其作为初始临床特征非常罕见。
