Perrone Erin E, Karmakar Monita, Lally Pamela A, Chung Sukyung, Kipfmueller Florian, Morini Francesco, Phillips Ryan, Van Meurs Krisa P, Harting Matthew T, Mychaliska George B, Lally Kevin P
Michigan Medicine, Department of Surgery, Section of Pediatric Surgery, Fetal Diagnosis and Treatment Center, University of Michigan, Ann Arbor, MI, USA.
Department of Pediatric Surgery, McGovern Medical School at UTHealth and Children's Memorial Hermann Hospital, Houston, TX, USA.
J Perinatol. 2022 Sep;42(9):1195-1201. doi: 10.1038/s41372-022-01357-x. Epub 2022 Feb 28.
To evaluate the association between prenatal imaging predictors of patients with left-sided congenital diaphragmatic hernia (LCDH) and postnatal outcomes.
CDH study group data were reviewed for LCDH infants born 2015-2019. Prenatal ultrasound (US) and magnetic resonance imaging (MRI) data were collected and correlated with postnatal information including CDHSG defect size (A through D or non-repair (NR)).
In total, 929 LCDH patients were included. Both US and MRI imaging predictors correlated with postnatal survival (72.2%) and ECLS use (29.6%). Logistic regression models confirmed increased survival and decreased ECLS use with larger values for all predictors. Importantly, all prenatal values evaluated showed no significant difference between defect size D and NR patients.
This is the largest cohort of LCDH patients and demonstrates that prenatal imaging factors correlate with postnatal outcomes and confirms that patients in the non-repair group are prenatally similar to type D defects.
评估左侧先天性膈疝（LCDH）患者的产前影像学预测指标与产后结局之间的关联。
回顾2015 - 2019年出生的LCDH婴儿的先天性膈疝（CDH）研究组数据。收集产前超声（US）和磁共振成像（MRI）数据，并将其与产后信息相关联，包括先天性膈疝研究组缺陷大小（A至D或非修复（NR））。
共纳入929例LCDH患者。超声和MRI成像预测指标均与产后生存率（72.2%）和体外膜肺氧合（ECLS）使用率（29.6%）相关。逻辑回归模型证实，所有预测指标值越大，生存率越高，ECLS使用率越低。重要的是，所有评估的产前值在缺陷大小D组和非修复组患者之间均无显著差异。
这是最大的LCDH患者队列，表明产前影像学因素与产后结局相关，并证实非修复组患者在产前与D型缺陷患者相似。
