肾移植后克雅氏病

Creutzfeldt-Jakob Disease Following Kidney Transplantation.

作者信息

Sharma Neeraj, Wang Lin, Namboodiri Hima

机构信息

University of Southern California Transplant, Department of Nephrology, University of Southern California, Los Angeles, USA.

Division of Nephrology and Hypertension, University of Southern California, Los Angeles, USA.

出版信息

Cureus. 2022 Jan 26;14(1):e21632. doi: 10.7759/cureus.21632. eCollection 2022 Jan.

DOI:10.7759/cureus.21632

PMID:35228978

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8878572/

Abstract

Neurologic complications after kidney transplantation are frequent and related to immunosuppressive therapy and vintage dialysis time, including comorbidities such as diabetes, hypertension, and cardiovascular diseases. Creutzfeldt-Jakob disease (CJD) is a very rare and rapidly fatal neurodegenerative disorder. Kidney transplant recipients present with mixed and complex neuropsychiatric manifestations, which makes diagnosis challenging. This case highlights the importance of enhancing awareness of the clinical presentation and timely diagnosis of this rare, fatal neurodegenerative disorder.

摘要

肾移植后的神经系统并发症很常见，与免疫抑制治疗及长期透析时间有关，还包括糖尿病、高血压和心血管疾病等合并症。克雅氏病（CJD）是一种非常罕见且迅速致命的神经退行性疾病。肾移植受者会出现复杂多样的神经精神症状，这使得诊断具有挑战性。本病例强调了提高对这种罕见致命神经退行性疾病临床表现的认识及及时诊断的重要性。