Joseph Abraham, Mushtaq Hisham, Zakhia George, Rohde Jonathan, Whiting Adria, Jama Abbas B, Khedr Anwar, Jain Nitesh K, Khan Syed Anjum
Hospital Medicine, Mayo Clinic Health System, Fairmont, USA.
Critical Care Medicine, Mayo Clinic Health System, Mankato, USA.
Cureus. 2022 May 7;14(5):e24812. doi: 10.7759/cureus.24812. eCollection 2022 May.
Sporadic Creutzfeldt-Jakob disease (CJD) is a rare neurodegenerative disorder, accounting for a majority of the sporadic prion disease burden. This disorder rapidly progresses and is often fatal with no known cure. Initial diagnosis may be delayed due to its varied presentations, which can include psychiatric changes (behavioural and mood variances), visual and auditory hallucinations, cerebellar dysfunction, and pain, occurring in isolation in many cases. Due to the nonspecific complaints, accurate diagnosis can be challenging. CJD exhibits symptoms similar to other neuropsychiatric illnesses; however, only a few reports have been published concerning the association between CJD and alcohol-related illnesses. This case report demonstrates the challenge of diagnosing this disorder early in the clinical course given the variable presentation, especially in a patient with a history of an alcohol use disorder, falls, and cognitive decline.
散发性克雅氏病（CJD）是一种罕见的神经退行性疾病，占散发性朊病毒病负担的大部分。这种疾病进展迅速，通常是致命的，目前尚无已知的治愈方法。由于其表现多样，初始诊断可能会延迟，这些表现包括精神变化（行为和情绪差异）、视觉和听觉幻觉、小脑功能障碍以及疼痛，在许多情况下这些症状会单独出现。由于症状不具特异性，准确诊断可能具有挑战性。CJD表现出与其他神经精神疾病相似的症状；然而，关于CJD与酒精相关疾病之间关联的报道很少。本病例报告表明，鉴于临床表现多样，在临床病程早期诊断这种疾病具有挑战性，尤其是对于有酒精使用障碍、跌倒和认知衰退病史的患者。
