Department of Cardiology, Beijing Anzhen Hospital, Capital Medical University, Beijing Institute of Heart Lung and Blood Vessel Disease, Beijing Key Laboratory of Precision Medicine of Coronary Atherosclerotic Disease, Clinical Center for Coronary Heart Disease, Capital Medical University, 100029 Beijing, China.
Rev Cardiovasc Med. 2022 Feb 17;23(2):66. doi: 10.31083/j.rcm2302066.
Patients that undergo renal transplantation (RT) often suffer from high rates of cardiovascular disease-related mortality, yet, most of the studies focus on coronary angiography performed as screening to entry in a waiting list and not, as for clinical indication, after renal transplantation.
This study examined coronary angiography findings from 45 patients with functional renal grafts for over 6 months that were analyzed in Anzhen Hospital (Beijing, China) from 2014-2019. For comparison purposes, we additionally examined coronary angiography findings from 45 age- and sex-matched patients undergoing chronic dialysis due to end-stage renal disease (ESRD). We used the SYNTAX score to gauge coronary artery disease (CAD) severity.
The duration of ESRD in patients in the RT group was significantly longer than for that of patients in the dialysis comparison group (19.31 ± 7.83 years vs. 11.43 ± 8.04 years, < 0.001). The SYNTAX scores for patients in the dialysis and RT groups were 17.76 ± 7.35 and 12.57 ± 5.61, respectively ( < 0.01). We found that 64.4% and 28.9% of dialysis and RT patients, respectively, exhibited the presence of moderate or severe calcified lesions upon examination. In addition, the SYNTAX scores of RT patients were correlated with ESRD duration ( < 0.001).
We observed less serious CAD in RT patients relative to long-term dialysis patients even though the former group exhibited a longer mean ESRD duration. Both groups exhibited high rates of calcification of the coronary artery, even following RT.
接受肾移植（RT）的患者常患有高心血管疾病相关死亡率，但大多数研究都集中在作为进入等候名单的筛选进行的冠状动脉造影，而不是在肾移植后进行临床指征的冠状动脉造影。
本研究检查了 2014 年至 2019 年期间在北京安贞医院进行的 45 例功能肾移植物超过 6 个月的患者的冠状动脉造影结果。为了比较目的，我们还检查了 45 例因终末期肾病（ESRD）接受慢性透析的年龄和性别匹配患者的冠状动脉造影结果。我们使用 SYNTAX 评分来评估冠状动脉疾病（CAD）的严重程度。
RT 组患者的 ESRD 持续时间明显长于透析比较组（19.31 ± 7.83 年比 11.43 ± 8.04 年， < 0.001）。透析组和 RT 组患者的 SYNTAX 评分分别为 17.76 ± 7.35 和 12.57 ± 5.61（ < 0.01）。我们发现，分别有 64.4%和 28.9%的透析和 RT 患者检查时存在中度或重度钙化病变。此外，RT 患者的 SYNTAX 评分与 ESRD 持续时间相关（ < 0.001）。
与长期透析患者相比，我们观察到 RT 患者的 CAD 严重程度较轻，尽管前者的 ESRD 持续时间较长。两组患者的冠状动脉钙化率都很高，甚至在 RT 后也是如此。
