Aortic and Vascular Surgery Center, Fuwai Hospital, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences and Peking Union Medical College, 100037 Beijing, China.
Shandong University, Qilu Hospital, 250012 Jinan, Shandong, China.
Rev Cardiovasc Med. 2022 Feb 17;23(2):67. doi: 10.31083/j.rcm2302067.
In view of the key role of inflammation in the pathogenesis of aortic disease, we visually analyzed the research hotspots of inflammatory mechanism in aortic disease in this work through the method of bibliometrics from the Web of Science (WOS) Core database over the past three decades.
A visual bibliometric network of research articles on inflammatory mechanisms in aortic disease was obtained from VOSviewer and Citespace based on the WOS Core Collection.
A total of 1278 documents from January 1990 to February 2021 were selected for analysis. The United States and China had the highest percentage of articles, comprising 34.01% and 24.92% of articles worldwide, respectively. Harvard University has published the most articles in this field, followed by the University of Michigan and Huazhong University of Science and Technology. The top 3 research hotspots were atherosclerosis, oxidative stress, and macrophages. The journal with the most articles in this area was Arteriosclerosis Thrombosis and Vascular Biology, followed by Atherosclerosis and PLOS One. The research trend on inflammatory mechanisms in the aortic system has 5 distinct directions: (1) atherosclerosis, NF-κB, expression, smooth muscle cell, and oxidative stress; (2) coronary artery disease, C-reactive protein, risk factors, endothelial dysfunction, and aortic stenosis; (3) abdominal aortic aneurysm, matrix metalloproteinases, macrophage, and pathogenesis; (4) cholesterol, metabolism, low-density lipoprotein, gene expression, and a therosclerotic lesions; and (5) calcific aortic valve disease, interstitial cells, calcification, and stenosis.
Inflammatory mechanism research has shown a tendency to rise gradually in the aortic field. Numerous studies have explored the role of inflammatory responses in aortic disease, which may increase the risk of endothelial dysfunction (aortic fibrosis and stiffness) and induce plaque formation. Among them, NFκB activation, nitric-oxide synthase expression, and oxidative stress are particularly essential.
鉴于炎症在主动脉疾病发病机制中的关键作用，我们通过文献计量学的方法，从过去三十年的 Web of Science（WOS）核心数据库中，对主动脉疾病炎症机制的研究热点进行了可视化分析。
利用 VOSviewer 和 Citespace 从 WOS 核心集获取主动脉疾病炎症机制研究文章的可视化文献计量网络。
共选取了 1990 年 1 月至 2021 年 2 月的 1278 篇文献进行分析。美国和中国发表的文章占比最高，分别占全球文章的 34.01%和 24.92%。哈佛大学在该领域发表的文章最多，其次是密歇根大学和华中科技大学。排名前三的研究热点是动脉粥样硬化、氧化应激和巨噬细胞。发表该领域文章最多的期刊是《动脉硬化、血栓形成和血管生物学》，其次是《动脉粥样硬化》和《PLOS ONE》。主动脉系统炎症机制的研究趋势有 5 个明显的方向：（1）动脉粥样硬化、NF-κB、表达、平滑肌细胞和氧化应激；（2）冠心病、C-反应蛋白、危险因素、内皮功能障碍和主动脉狭窄；（3）腹主动脉瘤、基质金属蛋白酶、巨噬细胞和发病机制；（4）胆固醇、代谢、低密度脂蛋白、基因表达和动脉粥样硬化病变；（5）钙化性主动脉瓣疾病、间质细胞、钙化和狭窄。
炎症机制研究在主动脉领域呈逐渐上升趋势。大量研究探讨了炎症反应在主动脉疾病中的作用，这可能增加内皮功能障碍（主动脉纤维化和僵硬）的风险，并诱导斑块形成。其中，NFκB 激活、一氧化氮合酶表达和氧化应激尤为重要。
