Department of Radiology, Sanjay Gandhi Postgraduate Institute of Medical Sciences, Lucknow, Uttar Pradesh, India.
Department of Urology and Renal Transplantation, Sanjay Gandhi Postgraduate Institute of Medical Sciences, Lucknow, Uttar Pradesh, India.
Saudi J Kidney Dis Transpl. 2021 Jul-Aug;32(4):993-998. doi: 10.4103/1319-2442.338312.
Computed tomography (CT) is routinely used for preoperative anatomical evaluation of renal donors, but recent studies show that it may be useful as a predictor of renal function too. This study aimed to compare CT volumetry-attenuation-based glomerular filtration rate (GFR) with Tc99m-diethylene-triamine-pentaacetic acid (DTPA) renal scintigraphy GFR and predict post-donor nephrectomy renal function. This is a prospective study involving 39 renal donors at a tertiary care hospital in northern India from 2014 to 2017. Renal volume and attenuation were determined by CT using a semiautomatic tool, and split renal function (SRF) was calculated for each side. CT-GFR was obtained using CT-SRF and global GFR from modification of diet in renal disease equation. At 12 months after nephrectomy, GFR was estimated from serum creatinine (eGFR). Predonation CT-GFR of preserved kidney was used to predict post-nephrectomy renal function which was compared with post-donation renal function calculated using serum creatinine as well as with DTPA-GFR. Pearson correlation coefficient and scatter diagram were used to assess and test the linear relationship between two continuous variables. The Statistical Package for the Social Sciences, version 23, was used for data analysis. There was a highly significant change in mean DTPA-GFR and mean CT-GFR compared to eGFR values (50.79-64.25, 26.50%, and 50.77-64.25, 26.55%, respectively). Similarly, there was a very good correlation between DTPA-GFR and eGFR (r = 0.968, P <0.001) as well as CT-GFR and eGFR (r = 0.968, P <0.001). CT volumetry-attenuation-based GFR accurately predicts post-donor nephrectomy renal function at 1 year similar to Tc99m-DTPA renal scintigraphy.
计算机断层扫描（CT）常用于术前评估肾脏供者的解剖结构，但最近的研究表明，它也可用于预测肾功能。本研究旨在比较基于 CT 容积衰减的肾小球滤过率（GFR）与 Tc99m-二乙三胺五乙酸（DTPA）肾闪烁照相术 GFR，并预测供肾切除术后的肾功能。这是一项在印度北部的一家三级护理医院进行的前瞻性研究，涉及 2014 年至 2017 年的 39 名肾脏供者。使用半自动工具通过 CT 确定肾脏体积和衰减，计算每侧的分肾功能（SRF）。CT-GFR 通过 CT-SRF 和改良肾脏病饮食方程的 GFR 获得。在肾切除术后 12 个月，通过血清肌酐估计 GFR（eGFR）。使用保留肾的术前 CT-GFR 预测肾切除术后的肾功能，并将其与使用血清肌酐计算的术后肾功能以及 DTPA-GFR 进行比较。使用 Pearson 相关系数和散点图评估和检验两个连续变量之间的线性关系。使用社会科学统计软件包，版本 23，进行数据分析。与 eGFR 值相比，DTPA-GFR 和 CT-GFR 的平均值有显著变化（分别为 50.79-64.25 和 26.50%，以及 50.77-64.25 和 26.55%）。同样，DTPA-GFR 与 eGFR 之间存在非常好的相关性（r = 0.968，P <0.001），CT-GFR 与 eGFR 之间也存在非常好的相关性（r = 0.968，P <0.001）。基于 CT 容积衰减的 GFR 可准确预测供肾切除术后 1 年的肾功能，与 Tc99m-DTPA 肾闪烁照相术相似。
