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慢性阻塞性肺疾病患者的新型冠状病毒肺炎感染:从病理生理学到治疗。迷你综述。

COVID-19 infection in patients with chronic obstructive pulmonary disease: From pathophysiology to therapy. Mini-review.

作者信息

Fekete Monika, Szarvas Zsofia, Fazekas-Pongor Vince, Feher Agnes, Dosa Norbert, Lehoczki Andrea, Tarantini Stefano, Varga Janos Tamas

机构信息

1 Department of Public Health, Semmelweis University, Faculty of Medicine, Budapest, Hungary.

2 Department of Hematology and Stem Cell Transplantation, National Institute for Hematology and Infectious Diseases, South Pest Central Hospital, Budapest, Hungary.

出版信息

Physiol Int. 2022 Feb 28. doi: 10.1556/2060.2022.00172.

Abstract

INTRODUCTION

Patients with chronic obstructive pulmonary disease (COPD) are a vulnerable group in terms of the outcome of coronavirus infection in relation to their disease or its treatment, with a higher risk of developing serious complications compared to the healthy population.

AIM

The aim of our summary study is to review the background and health outcomes of chronic obstructive pulmonary disease and COVID-19 infection in the presence of both diseases.

METHODS

Review of national and international medical databases (PubMed, MEDLINE, and MOB) with keywords COPD, COVID-19, disease risk, cause, prevention, complications, and prognosis.

RESULTS

Meta-analyses show that COPD is one of the most common underlying conditions in patients hospitalized for COVID-19. Such patients are five times more likely to develop a serious complication due to oxygen supply problems therefore they are more likely to be admitted to intensive care units, where they may require mechanical ventilation. In the case of underlying COPD, the usual care plan for COVID-19 infection should be followed, as well as all public health recommendations to minimize the risk of developing and transmitting COVID-19.

CONCLUSION

Coronavirus infection is especially dangerous for COPD patients, who are much more likely to become seriously ill, so increased surveillance, prevention, early detection, adequate treatment and rehabilitation of the disease group are of paramount importance.

摘要

引言

慢性阻塞性肺疾病(COPD)患者在冠状病毒感染结局方面,就其疾病或治疗而言是弱势群体,与健康人群相比,发生严重并发症的风险更高。

目的

我们这项综述研究的目的是回顾慢性阻塞性肺疾病与COVID-19感染并存时的背景情况及健康结局。

方法

通过关键词COPD、COVID-19、疾病风险、病因、预防、并发症和预后检索国内外医学数据库(PubMed、MEDLINE和MOB)。

结果

荟萃分析表明,COPD是因COVID-19住院患者中最常见的基础疾病之一。此类患者因供氧问题发生严重并发症的可能性高出五倍,因此更有可能入住重症监护病房,可能需要机械通气。对于存在COPD基础疾病的情况,应遵循COVID-19感染的常规护理方案以及所有公共卫生建议,以尽量降低发生和传播COVID-19的风险。

结论

冠状病毒感染对COPD患者尤其危险,他们更易患重病,因此加强对该疾病群体的监测、预防、早期检测、充分治疗和康复至关重要。

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