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关于中国孕妇和哺乳期妇女接种严重急性呼吸综合征冠状病毒 2 疫苗的思考。

How to think about severe acute respiratory syndrome coronavirus 2 vaccination for pregnant and lactating women in China.

机构信息

Department of Obstetrics, Xiangya Hospital, Central South University, Changsha 410008.

Hunan Engineering Research Center of Early Life Development and Disease Prevention, Changsha 410008.

出版信息

Zhong Nan Da Xue Xue Bao Yi Xue Ban. 2021 Dec 28;46(12):1386-1391. doi: 10.11817/j.issn.1672-7347.2021.210637.

Abstract

The coronavirus disease 2019 (COVID-19) continues to spread around the world, and how to build an immune barrier against the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) in the population is the work we need to do for a long time in the future. The vaccination is an important strategy to construct and improve the herd immunity barrier. Therefore, our country is currently actively and extensively implementing the anti-epidemic policy of SARS-CoV-2 vaccination. However, because of insufficient data on the safety of the SARS-CoV-2 vaccine in the population, especially the lack of clinical research in pregnant and lactating women, China has adopted a conservative approach on whether women in this special physiological period receive SARS-CoV-2 vaccine based on the safe consideration. However, with the widespread application of the SARS-CoV-2 vaccine in the prevention and control of the global epidemic, and the emergence of a large number of clinical research evidences at home and abroad, if we still exclude pregnant and lactating women from the vaccinated population, this part of the population will be fully exposed to the SARS-CoV-2 threat, which will weak the national prevention and control policy. Therefore, it is necessary to reconsider the vaccination of people in this special physiological period based on the experience of vaccination at home and abroad.

摘要

新型冠状病毒肺炎(COVID-19)仍在全球范围内传播,如何在人群中建立针对严重急性呼吸综合征冠状病毒 2(SARS-CoV-2)的免疫屏障是我们在未来很长一段时间内需要做的工作。疫苗接种是构建和提高群体免疫屏障的重要策略。因此,我国目前正在积极广泛地实施 SARS-CoV-2 疫苗的防疫政策。然而,由于人群中 SARS-CoV-2 疫苗的安全性数据不足,特别是缺乏对孕妇和哺乳期妇女的临床研究,中国基于安全考虑对这一特殊生理时期的妇女是否接种 SARS-CoV-2 疫苗采取了保守的方法。然而,随着 SARS-CoV-2 疫苗在全球疫情防控中的广泛应用,以及国内外大量临床研究证据的出现,如果我们仍然将孕妇和哺乳期妇女排除在接种人群之外,这部分人群将完全暴露于 SARS-CoV-2 的威胁之下,这将削弱国家的防控政策。因此,有必要根据国内外的接种经验,重新考虑这一特殊生理时期人群的接种问题。

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本文引用的文献

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Preliminary Findings of mRNA Covid-19 Vaccine Safety in Pregnant Persons.mRNA 新冠疫苗在孕妇中的初步安全性研究结果。
N Engl J Med. 2021 Jun 17;384(24):2273-2282. doi: 10.1056/NEJMoa2104983. Epub 2021 Apr 21.

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