Wang Peng-Hui, Lee Wen-Ling, Yang Szu-Ting, Tsui Kuan-Hao, Chang Cheng-Chang, Lee Fa-Kung
Department of Obstetrics and Gynecology, Taipei Veterans General Hospital, Taipei, Taiwan, ROC.
Institute of Clinical Medicine, National Yang Ming Chiao Tung University, Taipei, Taiwan, ROC.
J Chin Med Assoc. 2021 Oct 1;84(10):903-910. doi: 10.1097/JCMA.0000000000000612.
Effective strategies are urgently needed to decrease the risk of untoward outcomes of pregnant women with severe acute respiratory syndrome coronavirus 2 (coronavirus disease 2019 [COVID-19]) infection. Pregnant women are a vulnerable population to infectious disease pandemics with dramatically increased infectious diseases-related serious complications, such as the need of hospitalizations, the need of admission to intensive care unit, and the final disease-related death compared with those nonpregnant counterparts or those pregnant women without infection. Several studies have shown that vaccinations in pregnancy are a safe and highly effective strategy, not only for pregnant women but also for fetus and/or newborn because of the passive transplacental transfer of antibodies to the offspring. Active and passive prevention of infectious diseases is approved as effective strategies for women who attempt to become pregnant or during pregnancy. Despite the large and proven scientific evidence, pregnant women still puzzle over whether they should get vaccinated. The question therefore arises: Why are pregnant women so reluctant to receive vaccination? The explanation is more likely in the way that the benefits of vaccination have been communicated "confusedly." In fact, like virtually all clinical trials, all the COVID-19 vaccine trials have excluded pregnant and lactating women from participating, contributing to uncertainty of safety and efficacy in COVID-19 vaccines that have been well prepared and available for the general adult population worldwide. Moreover, messenger RNA vaccine is a relatively brand-new vaccine, and experience with this type of vaccine is still scarce. It is hard to overcome this innovation deadlock. The knowledge and awareness of pregnant women who are at risk, and full information on the knowledge of vaccines and related preventable diseases in pregnant women may avoid hesitancy and increase vaccine acceptance. The current review is a part two addressing the impact of COVID-19 on pregnant women. We focus on the up-to-date information about the application of vaccination on pregnant women, especially during this COVID-19 pandemic.
迫切需要有效的策略来降低感染严重急性呼吸综合征冠状病毒2（2019冠状病毒病[COVID-19]）的孕妇出现不良后果的风险。孕妇是传染病大流行的易感人群，与未怀孕的同龄人或未感染的孕妇相比，她们因传染病导致的严重并发症显著增加，如需要住院、入住重症监护病房以及最终因疾病死亡。多项研究表明，孕期接种疫苗是一种安全且高效的策略，不仅对孕妇有益，对胎儿和/或新生儿也有益，因为抗体可通过胎盘被动转移给后代。主动和被动预防传染病被认为是对试图怀孕的女性或孕期女性有效的策略。尽管有大量确凿的科学证据，但孕妇仍对是否应该接种疫苗感到困惑。因此问题来了：为什么孕妇如此不愿意接种疫苗？更有可能的解释是疫苗的益处传达得“混乱不清”。事实上，与几乎所有临床试验一样，所有COVID-19疫苗试验都将孕妇和哺乳期妇女排除在参与范围之外，这导致了已为全球普通成年人群充分准备并可用的COVID-19疫苗在安全性和有效性方面存在不确定性。此外，信使核糖核酸疫苗是一种相对较新的疫苗，这类疫苗的经验仍然很少。很难打破这种创新僵局。了解处于风险中的孕妇的知识和意识，以及向孕妇充分提供有关疫苗和相关可预防疾病的知识信息，可能会避免犹豫并提高疫苗接种率。本综述是关于COVID-19对孕妇影响的第二篇文章。我们关注关于疫苗接种在孕妇中的应用的最新信息，尤其是在这次COVID-19大流行期间。
