快速眼动睡眠行为障碍的研究进展。
Research progress in rapid eye movement sleep behavior disorder.
机构信息
Department of Neurology, Second Xiangya Hospital, Central South University, Changsha 410011, China.
出版信息
Zhong Nan Da Xue Xue Bao Yi Xue Ban. 2021 Dec 28;46(12):1415-1422. doi: 10.11817/j.issn.1672-7347.2021.200928.
Abstract
Rapid eye movement (REM) sleep behavior disorder (RBD) is characterized by abnormal dream acting behavior such as vocalization and twitching related to dream content during REM sleep. The diagnosis requires polysomnography demonstrating a loss of normal skeletal muscle atonia during REM sleep. Both idiopathic RBD and secondary RBD are highly related to synucleinopathy including Parkinson's disease, dementia with Lewy bodies, and multiple system atrophy. Almost all idiopathic RBD patients will develop synucleinopathy after a few years. Therefore, RBD may be an early marker in the progression of synucleinopathy.
摘要
快速眼动（REM）睡眠行为障碍（RBD）的特征是 REM 睡眠期间与梦境内容相关的异常梦动行为，如发声和抽搐。诊断需要多导睡眠图显示 REM 睡眠期间正常骨骼肌弛缓消失。特发性 RBD 和继发性 RBD 均与包括帕金森病、路易体痴呆和多系统萎缩在内的突触核蛋白病密切相关。几乎所有特发性 RBD 患者在几年后都会发展为突触核蛋白病。因此，RBD 可能是突触核蛋白病进展的早期标志物。
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本文引用的文献
1
Risk factors for possible REM sleep behavior disorders: A community-based study in Beijing.可能 REM 睡眠行为障碍的危险因素：一项基于社区的北京研究。
Neurology. 2020 Oct 20;95(16):e2214-e2224. doi: 10.1212/WNL.0000000000010610. Epub 2020 Aug 11.
2
Clinical trials in REM sleep behavioural disorder: challenges and opportunities.快速眼动睡眠行为障碍的临床试验：挑战与机遇。
J Neurol Neurosurg Psychiatry. 2020 Jul;91(7):740-749. doi: 10.1136/jnnp-2020-322875. Epub 2020 May 13.
3
Fine-Mapping of SNCA in Rapid Eye Movement Sleep Behavior Disorder and Overt Synucleinopathies.快速眼动睡眠行为障碍和显性神经核内包涵体病中 SNCA 的精细定位。
Ann Neurol. 2020 Apr;87(4):584-598. doi: 10.1002/ana.25687. Epub 2020 Feb 12.
4
Genetic, Structural, and Functional Evidence Link TMEM175 to Synucleinopathies.遗传、结构和功能证据将 TMEM175 与突触核蛋白病联系起来。
Ann Neurol. 2020 Jan;87(1):139-153. doi: 10.1002/ana.25629. Epub 2019 Nov 18.
5
Orthostatic hypotension and REM sleep behaviour disorder: impact on clinical outcomes in α-synucleinopathies.直立性低血压和 REM 睡眠行为障碍：对 α-突触核蛋白病临床结局的影响。
J Neurol Neurosurg Psychiatry. 2019 Nov;90(11):1257-1263. doi: 10.1136/jnnp-2019-320846. Epub 2019 May 29.
6
Evolution of prodromal Parkinson's disease and dementia with Lewy bodies: a prospective study.前驱期帕金森病和路易体痴呆的演变：一项前瞻性研究。
Brain. 2019 Jul 1;142(7):2051-2067. doi: 10.1093/brain/awz111.
7
Risk and predictors of dementia and parkinsonism in idiopathic REM sleep behaviour disorder: a multicentre study.特发性 REM 睡眠行为障碍患者发生痴呆和帕金森病的风险及预测因素：一项多中心研究。
Brain. 2019 Mar 1;142(3):744-759. doi: 10.1093/brain/awz030.
8
The risk of neurodegeneration in REM sleep behavior disorder: A systematic review and meta-analysis of longitudinal studies.快速眼动睡眠行为障碍与神经退行性变风险：纵向研究的系统回顾和荟萃分析。
Sleep Med Rev. 2019 Feb;43:37-46. doi: 10.1016/j.smrv.2018.09.008. Epub 2018 Nov 8.
9
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Nat Rev Dis Primers. 2018 Aug 30;4(1):19. doi: 10.1038/s41572-018-0016-5.
10
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Clin Neurophysiol. 2018 Aug;129(8):1551-1564. doi: 10.1016/j.clinph.2018.05.003. Epub 2018 May 29.
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