CT-guided trans-sternal iodine-125 seeds implantation for masses in the anterior or middle mediastinum.

PURPOSE

The aim of this study was to explore the feasibility and clinical value of computed tomography (CT)-guided trans-sternal puncture to implant I seeds to treat masses in the anterior or middle mediastinum.

MATERIAL AND METHODS

From September 2017 to December 2019, twenty patients with masses in the anterior or middle mediastinum were enrolled and treated with CT-guided trans-sternal I seeds implantation. Dosimetry parameters were compared between post-operative and pre-operative plans. Satisfaction rate of I seed distribution, complications, and local efficacy were evaluated.

RESULTS

A total of 22 lesions were treated with I implantation in twenty patients, all procedures being successfully completed. The dosimetry parameters of the 20 patients immediately after surgery were as follows: mean D = 134.30 ±14.53 Gy; mean V, V, V, and V were 96.10 ±1.55%, 92.69 ±1.93%, 66.86 ±7.53%, and 42.95 ±9.11%, respectively; mean conformity index (CI), external index (EI), and homogeneity index (HI) were 0.65 ±0.06, 40.79 ±13.72%, and 27.90 ±7.53%, respectively. The satisfaction rate of I seed distribution was 90%. The mean follow-up duration was 12 ±4.75 months (range, 4-24 months). The local control rates of 2 months, 6 months, and 1 year after surgery were 65.0%, 64.7%, and 53.8%, respectively. One patient had a small degree of pneumothorax, and one had hemoptysis after surgery.

CONCLUSIONS

CT-guided trans-sternal puncture plant I seeds for the treatment of masses in the anterior or middle mediastinum might serve as an alternative approach for treating specific mediastinal metastatic tumors.