Hoffmanns H W, Altmeier G
Onkologie. 1986 Feb;9(1):27-9. doi: 10.1159/000215955.
Two cases histories demonstrate the efficacy of mitoxantrone, a cytotoxic substance, after local application in inoperable, recurrent esophageal carcinoma. The drug is well tolerated. Local or systemic side-effects have not been observed so far. Up to 20 mg of mitoxantrone were administered at multiple sites into the tumor mass via the esophageal sclerosing system. So far the technique has been applied in 5 cases, and in each one we observed a transitory subjective and objective response.
两个病例史证明了米托蒽醌（一种细胞毒性物质）在局部应用于无法手术的复发性食管癌时的疗效。该药物耐受性良好。目前尚未观察到局部或全身副作用。通过食管硬化系统在多个部位向肿瘤块中注射高达20毫克的米托蒽醌。到目前为止，该技术已应用于5例患者，并且在每例患者中我们都观察到了短暂的主观和客观反应。
