Peng T, Nisengard R J, Levine M J
Oral Surg Oral Med Oral Pathol. 1986 Jun;61(6):584-9. doi: 10.1016/0030-4220(86)90100-3.
Desquamative gingival lesions are a clinical manifestation of several entities where histologic alterations in the gingival basement membrane are frequent. Normal and lesional gingival specimens from six patients with desquamative lesions of the gingiva associated with cicatricial pemphigoid or lichen planus and from one normal subject were examined by indirect immunofluorescence for immunologic alterations in basement membrane antigens. In four out of five desquamative gingival lesions from patients with lichen planus, type IV collagen and EBA basement membrane antigens were interrupted, thickened, or partially or completely absent as compared to normal gingiva. One specimen showed multiplication and duplication of the basement membrane. In the two desquamative gingival lesions from patients with cicatricial pemphigoid, type IV collagen was either partially absent or associated with the connective tissue side of the subepithelial bullae. These results suggest structural alterations in antigens within the basement membrane of patients with desquamative lesions of the gingiva.
剥脱性龈病损是多种疾病的临床表现，其中牙龈基底膜的组织学改变较为常见。对6例与瘢痕性类天疱疮或扁平苔藓相关的剥脱性龈病损患者及1例正常受试者的正常和病损牙龈标本进行间接免疫荧光检查，以检测基底膜抗原的免疫改变。与正常牙龈相比，5例扁平苔藓患者的剥脱性龈病损中有4例，IV型胶原和EBA基底膜抗原出现中断、增厚或部分或完全缺失。1份标本显示基底膜增殖和重复。在2例瘢痕性类天疱疮患者的剥脱性龈病损中，IV型胶原要么部分缺失，要么与上皮下大疱的结缔组织侧相关。这些结果提示牙龈剥脱性病变患者基底膜内抗原存在结构改变。
