Layman Paul R, Argyras Eri, Glynn Christopher J
Nuffield Department of Anaesthetics, John Radcliffe Hospital, OxfordU.K. Oxford Regional Pain Relief Unit, AbingdonU.K. Department of Anaesthetics, University of Athens, AthensGreece Oxford Regional Pain Relief Unit, Abingdon, and Nuffield Department of Anaesthetics, Radcliffe Infirmary, OxfordU.K.
Pain. 1986 May;25(2):165-170. doi: 10.1016/0304-3959(86)90090-4.
Twenty patients with post-herpetic neuralgia (median duration 28.5 months) were randomly allocated to receive transdermal iontophoresis of either vincristine or saline. Although significant improvement in pain by word score and visual analogue scale (P = 0.05) was reported by 6 out of 10 of the vincristine group, none of the patients considered themselves 'cured.' There was no significant change in the saline group. No adverse haematological or neurological side effects were seen, but skin irritation and painless electrical burns were common in both groups. The dramatic relief of pain in patients with post-herpetic neuralgia of 3 months or less reported elsewhere was not seen in our group who had pain of a longer duration. This present trial does not confirm the value of vincristine iontophoresis in the treatment of post-herpetic neuralgia of over 6 months duration.
20例带状疱疹后神经痛患者（中位病程28.5个月）被随机分配接受长春新碱或生理盐水的经皮离子导入治疗。虽然长春新碱组10例中有6例报告疼痛在文字评分和视觉模拟量表上有显著改善（P = 0.05），但没有患者认为自己“治愈”。生理盐水组无显著变化。未观察到血液学或神经系统的不良副作用，但两组均常见皮肤刺激和无痛性电灼伤。在我们这群病程较长的患者中，未见到其他地方所报告的病程3个月或更短的带状疱疹后神经痛患者出现的疼痛显著缓解情况。本试验未证实长春新碱离子导入治疗病程超过6个月的带状疱疹后神经痛的价值。
