13726Kin-ikyo Chuo Hospital, Sapporo, Japan.
Japan Baptist Hospital, Kyoto, Japan.
Int J Surg Pathol. 2022 Oct;30(7):828-838. doi: 10.1177/10668969221081432. Epub 2022 Mar 2.
Hairy cell leukemia-Japanese variant (HCL-jv) shares some features with, but differs in other features from, HCL variant. Recently, it has been pointed out that HCL-jv and splenic diffuse red pulp small B-cell lymphoma (SDRPL) possibly constitute the same disease. We report a patient with HCL-jv, in which the neoplastic cells in the resected spleen were positive for CD11c, CD103, tartrate-resistant acid phosphatase (by immunohistochemistry), and weakly positive for cyclin D3. They were negative for CD25, CD123, annexin A1, and V600E-derived protein. Meta-analysis of HCL-jv cases in the literature showed considerable variation in the expression of HCL-related molecules. Although the clinical features and pattern of splenic involvement of HCL-jv are similar to those of SDRPL, some cytomorphological and phenotypical differences can be pointed out. To confirm whether the weak expression of cyclin D3 in our case suggests a spectrum from HCL-jv to SDRPL or one of the characteristics of HCL-jv, further studies on a large number of cases are necessary.
日本型毛细胞白血病（HCL-jv）与 HCL 变异型有一些共同特征，但也有其他不同之处。最近，有人指出 HCL-jv 和脾弥漫性红髓小 B 细胞淋巴瘤（SDRPL）可能是同一种疾病。我们报告了一例 HCL-jv 患者，切除的脾脏中的肿瘤细胞 CD11c、CD103、耐酒石酸酸性磷酸酶（免疫组化）阳性，cyclin D3 弱阳性。它们 CD25、CD123、膜联蛋白 A1 和 V600E 衍生蛋白阴性。对文献中 HCL-jv 病例的荟萃分析表明，HCL 相关分子的表达存在相当大的差异。尽管 HCL-jv 的临床特征和脾脏受累模式与 SDRPL 相似，但仍可指出一些细胞形态学和表型上的差异。为了确定我们病例中 cyclin D3 的弱表达是否提示从 HCL-jv 到 SDRPL 的范围，或者是 HCL-jv 的特征之一，需要对大量病例进行进一步研究。
