O'Bryant Sid E, Petersen Melissa, Hall James, Johnson Leigh A
Institute for Translational Research, University of North Texas Health Science Center, Fort Worth, Texas, USA.
Department of Family Medicine, University of North Texas Health Science Center, Fort Worth, Texas, USA.
Alzheimers Dement. 2023 Jan;19(1):36-43. doi: 10.1002/alz.12647. Epub 2022 Mar 2.
Despite the clinical implementation, there remain significant gaps in our knowledge regarding the impact of race/ethnicity or common medical comorbidity on plasma Alzheimer's disease (AD) biomarkers.
Plasma biomarkers of amyloid beta (Aβ) Aβ , total tau, and neurofilament light chain (NfL) were measured across cognitively normal Mexican Americans (n = 445) and non-Hispanic Whites (n = 520).
Dyslipidemia was associated with elevated Aβ (P = .01) and Aβ (P = .001) while hypertension was associated with elevated Aβ (P = .003), Aβ (P < .001), and total tau (P = .002) levels. Diabetes was associated with higher Aβ (P < .001), Aβ (P < .001), total tau (P < .001), and NfL (P < .001) levels. Chronic kidney disease (CKD) was associated with elevations in Aβ (P < .001), Aβ (P < .001), total tau (P < .001), and NfL (P < .001) levels. Mexican Americans had significantly lower Aβ (P < .001) and higher total tau (P = .005) levels.
Plasma AD biomarkers vary significantly in association with common medical comorbidities as well as ethnicity. These findings are important for those using these biomarkers in clinical practice and clinical trials.
尽管已在临床中应用，但我们对种族/族裔或常见医学合并症对血浆阿尔茨海默病（AD）生物标志物的影响仍知之甚少。
对445名认知正常的墨西哥裔美国人以及520名非西班牙裔白人测量了淀粉样β蛋白（Aβ）、总tau蛋白和神经丝轻链（NfL）的血浆生物标志物。
血脂异常与Aβ升高（P = 0.01）和Aβ升高（P = 0.001）相关，而高血压与Aβ升高（P = 0.003）、Aβ升高（P < 0.001）和总tau蛋白升高（P = 0.002）相关。糖尿病与更高的Aβ水平（P < 0.001）、Aβ水平（P < 0.001）、总tau蛋白水平（P < 0.001）和NfL水平（P < 0.001）相关。慢性肾脏病（CKD）与Aβ水平升高（P < 0.001）、Aβ水平升高（P < 0.001）、总tau蛋白水平升高（P < 0.001）和NfL水平升高（P < 0.001）相关。墨西哥裔美国人的Aβ水平显著较低（P < 0.001），总tau蛋白水平较高（P = 0.005）。
血浆AD生物标志物因常见医学合并症和种族的不同而有显著差异。这些发现对在临床实践和临床试验中使用这些生物标志物的人来说很重要。
