Department of Biochemistry, Karpagam Academy of Higher Education, Coimbatore, Tamil Nadu, 641 021, India.
Karpagam Cancer Research Centre, Karpagam Academy of Higher Education, Coimbatore, Tamil Nadu, 641 021, India.
Curr Pharm Des. 2022;28(11):922-946. doi: 10.2174/1381612828666220302153201.
Metastasis of primary pancreatic cancer (PC) to adjacent or distant organs is responsible for the poor survival rate of affected individuals. Chemotherapy, radiotherapy, and immunotherapy are currently being prescribed to treat PC in addition to surgical resection. Surgical resection is the preferred treatment for PC that leads to 20% of 5-year survival, but only less than 20% of patients are eligible for surgical resection because of the poor prognosis. To improve the prognosis and clinical outcome, early diagnostic markers need to be identified, and targeting them would be of immense benefit to increase the efficiency of the treatment. Cell migration-inducing hyaluronan-binding protein (CEMIP) is identified as an important risk factor for the metastasis of various cancers, including PC. Emerging studies have pointed out the crucial role of CEMIP in the regulation of various signaling mechanisms, leading to enhanced migration and metastasis of PC.
The published findings on PC metastasis, phytoconstituents, and CEMIP were retrieved from Pubmed, ScienceDirect, and Cochrane Library. Computational tools, such as gene expression profiling interactive analysis (GEPIA) and Kaplan-Meier (KM) plotter, were used to study the relationship between CEMIP expression and survival of PC individuals.
Gene expression analysis using the GEPIA database identified a stupendous increase in the CEMIP transcript in PC compared to adjacent normal tissues. KM plotter analysis revealed the impact of CEMIP on the overall survival (OS) and disease-free survival (DFS) among PC patients. Subsequently, several risk factors associated with PC development were screened, and their ability to regulate CEMIP gene expression was analyzed using computational tools.
The current review is focused on gathering information regarding the regulatory role of phytocomponents in PC migration and exploring their possible impact on the CEMIP expression.
原发性胰腺癌（PC）转移到邻近或远处器官是导致受影响个体生存率低的原因。除了手术切除外，目前还规定了化疗、放疗和免疫疗法来治疗 PC。手术切除是治疗 PC 的首选方法，导致 5 年生存率达到 20%，但由于预后不良，只有不到 20%的患者适合手术切除。为了改善预后和临床结果，需要确定早期诊断标志物，针对这些标志物将极大地有助于提高治疗效率。细胞迁移诱导透明质酸结合蛋白（CEMIP）被确定为包括 PC 在内的各种癌症转移的重要危险因素。新出现的研究指出 CEMIP 在调节各种信号机制中的关键作用，导致 PC 的迁移和转移增强。
从 Pubmed、ScienceDirect 和 Cochrane Library 检索了关于 PC 转移、植物成分和 CEMIP 的已发表发现。使用基因表达谱交互分析（GEPIA）和 Kaplan-Meier（KM）绘图器等计算工具研究了 CEMIP 表达与 PC 个体生存之间的关系。
使用 GEPIA 数据库进行基因表达分析，发现与相邻正常组织相比，PC 中 CEMIP 转录本显著增加。KM 绘图器分析显示了 CEMIP 对 PC 患者总体生存率（OS）和无病生存率（DFS）的影响。随后，筛选了与 PC 发展相关的几个风险因素，并使用计算工具分析了它们调节 CEMIP 基因表达的能力。
本综述重点收集有关植物成分在 PC 迁移中的调节作用的信息，并探讨它们对 CEMIP 表达的可能影响。
