Department of Pulmonary Medicine, Postgraduate Institute of Medical Education and Research, Sector-12, Chandigarh 160012, India.
Department of Pulmonary Medicine, Postgraduate Institute of Medical Education and Research, Sector-12, Chandigarh 160012, India.
Clin Chest Med. 2022 Mar;43(1):99-125. doi: 10.1016/j.ccm.2021.12.002.
Allergic bronchopulmonary aspergillosis (ABPA) is a complex allergic disorder caused by immune reactions against Aspergillus fumigatus. ABPA most commonly complicates the course of patients with poorly controlled asthma. Patients commonly present with uncontrolled asthma, fleeting pulmonary opacities, and bronchiectasis. Pathogenetically, ABPA is characterized by the persistence of A. fumigatus in the airways and an exaggerated type-2 immune response. The interest in ABPA stems from the fact that bronchiectasis in ABPA can be prevented if the disorder is diagnosed timely and treated appropriately. Herein, we summarize the current concepts in the epidemiology, pathogenesis, diagnosis, and treatment of ABPA.
变应性支气管肺曲霉病（ABPA）是一种由免疫反应引起的复杂过敏性疾病，由烟曲霉引起。ABPA 最常合并控制不佳的哮喘患者。患者通常表现为哮喘控制不佳、短暂性肺部阴影和支气管扩张。从发病机制上讲，ABPA 的特征是烟曲霉在气道中持续存在和 2 型免疫反应过度。人们对 ABPA 的兴趣源于这样一个事实，即如果及时诊断和适当治疗，ABPA 引起的支气管扩张是可以预防的。在此，我们总结了 ABPA 的流行病学、发病机制、诊断和治疗的最新概念。
