The Institute of Cardiovascular Diseases, and Department of Cardiovascular Surgery, TEDA International Cardiovascular Hospital, Tianjin University and Chinese Academy of Medical Sciences.
Unit of Perfusion, Department of Cardiovascular Surgery, TEDA International Cardiovascular Hospital.
Acta Med Okayama. 2022 Feb;76(1):33-39. doi: 10.18926/AMO/63206.
Trace elements selenium (Se) and cobalt (Co) are essential in the human body, and a correlation between Se and cardiac surgery has been suggested. We investigated the plasma concentrations of Se and Co during and after coronary artery bypass grafting (CABG) surgery under cardiopulmonary bypass (CPB). From December 2019 to January 2020, preoperative plasma samples from isolated first-time CABG patients (n=20; 10 males, 10 females) were prospectively collected post-anesthesia and before CPB (T1), 45 min after CPB started (T2), 90 min after CPB started (T3), and postoperative days 1 (T4), and day 4 (T5). The plasma concentrations of Se and Co were measured. The Se concentration was significantly decreased at T2 (105.24±4.08 vs. 68.56±2.42 μg/L, p<0.001) and T3 (105.24±4.08 vs. 80.41±3.40 μg/L, p<0.001). The Co concentration was significantly decreased at T4 (0.35±0.19 vs. 0.26±0.13 μg/L, p<0.01) and T5 (0.35±0.19 vs. 0.23±0.11 μg/L, p<0.001). Five patients developed atrial fibrillation (AF); there was no other operative mortality or major morbidity. This is the first report of alterations of plasma Se and Co concentrations during and after CABG surgery. Our results may indicate that Se supplementation before or during CABG and Co supplementation after CABG may become necessary for patients undergoing CABG.
微量元素硒 (Se) 和钴 (Co) 是人体必需的，并且已经有人提出 Se 与心脏手术之间存在相关性。我们研究了体外循环 (CPB) 下冠状动脉旁路移植术 (CABG) 期间和之后血浆中 Se 和 Co 的浓度。从 2019 年 12 月到 2020 年 1 月，前瞻性收集了首次接受 CABG 手术的孤立患者（n=20；男性 10 例，女性 10 例）的术前血浆样本，在麻醉后和 CPB 前（T1）、CPB 开始后 45 分钟（T2）、CPB 开始后 90 分钟（T3）和术后第 1 天（T4）和第 4 天（T5）。测量了 Se 和 Co 的血浆浓度。T2（105.24±4.08 对 68.56±2.42 μg/L，p<0.001）和 T3（105.24±4.08 对 80.41±3.40 μg/L，p<0.001）时 Se 浓度明显降低。T4（0.35±0.19 对 0.26±0.13 μg/L，p<0.01）和 T5（0.35±0.19 对 0.23±0.11 μg/L，p<0.001）时 Co 浓度明显降低。5 例患者发生心房颤动 (AF)；无其他手术死亡或重大并发症。这是首次报道 CABG 手术期间和之后血浆 Se 和 Co 浓度的变化。我们的结果可能表明，在 CABG 之前或期间进行 Se 补充，以及在 CABG 之后进行 Co 补充，对于接受 CABG 的患者可能是必要的。
