Ye Lingqing, Taylor Graham P, Rosadas Carolina
Section of Virology, Department of Infectious Disease, Imperial College London, London, United Kingdom.
National Centre for Human Retrovirology, St. Mary's Hospital, Imperial College Healthcare NHS Trust, London, United Kingdom.
Front Med (Lausanne). 2022 Feb 14;9:832430. doi: 10.3389/fmed.2022.832430. eCollection 2022.
The distribution of human T cell lymphotropic virus type 1 (HTLV-1) overlaps with that of . infection has been reported to be impacted by co-infection with HTLV-1. Disseminated strongyloidiasis and hyperinfection syndrome, which are commonly fatal, are observed in HTLV-1 co-infected patients. Reduced efficacy of anti-strongyloidiasis treatment in HTLV-1 carriers has been reported. The aim of this meta-analysis and systematic review is to better understand the association between HTLV-1 and infection.
PubMed, Embase, MEDLINE, Global Health, Healthcare Management Information Consortium databases were searched. Studies regarding the prevalence of , those evaluating the frequency of mild or severe strongyloidiasis, and treatment response in people living with and without HTLV-1 infection were included. Data were extracted and odds ratios were calculated. Random-effect meta-analysis was used to assess the pooled OR and 95% confidence intervals.
Fourteen studies were included after full-text reviewing of which seven described the prevalence of and HTLV-1. The odds of infection were higher in HTLV-1 carriers when compared with HTLV-1 seronegative subjects (OR 3.2 95%CI 1.7-6.2). A strong association was found between severe strongyloidiasis and HTLV-1 infection (OR 59.9, 95%CI 18.1-198). Co-infection with HTLV-1 was associated with a higher rate of strongyloidiasis treatment failure (OR 5.05, 95%CI 2.5-10.1).
infection is more prevalent in people living with HTLV-1. Co-infected patients are more likely to develop severe presentation and to fail treatment. Screening for HTLV-1 and sp. should be routine when either is diagnosed.
人类嗜T淋巴细胞病毒1型（HTLV-1）的分布与[某种寄生虫名称]的分布重叠。据报道，[某种寄生虫名称]感染会受到HTLV-1合并感染的影响。在HTLV-1合并感染的患者中可观察到播散性类圆线虫病和超感染综合征，这些通常是致命的。据报道，HTLV-1携带者抗类圆线虫病治疗的疗效降低。本荟萃分析和系统评价的目的是更好地了解HTLV-1与[某种寄生虫名称]感染之间的关联。
检索了PubMed、Embase、MEDLINE、Global Health、医疗保健管理信息联盟数据库。纳入了关于[某种寄生虫名称]患病率的研究、评估轻度或重度类圆线虫病频率的研究，以及有或无HTLV-1感染人群的治疗反应研究。提取数据并计算比值比。采用随机效应荟萃分析评估合并的比值比和95%置信区间。
经过全文审查后纳入了14项研究，其中7项描述了[某种寄生虫名称]和HTLV-1的患病率。与HTLV-1血清阴性受试者相比，HTLV-1携带者感染[某种寄生虫名称]的几率更高（比值比3.2，95%置信区间1.7 - 6.2）。在重度类圆线虫病与HTLV-1感染之间发现了强关联（比值比59.9，95%置信区间18.1 - 198）。HTLV-1合并感染与类圆线虫病治疗失败率较高相关（比值比5.05，95%置信区间2.5 - 10.1）。
[某种寄生虫名称]感染在HTLV-1感染者中更为普遍。合并感染的患者更有可能出现严重症状且治疗失败。当诊断出HTLV-1或[某种寄生虫名称]时，对HTLV-1和[某种寄生虫名称]的筛查应成为常规操作。
