Kroenke Eve, Ankar Alex, Malani Shukla Nikita
Texas Children's Hospital/Baylor College of Medicine, Houston, TX.
Child Neurol Open. 2022 Feb 25;9:2329048X221079093. doi: 10.1177/2329048X221079093. eCollection 2022 Jan-Dec.
MOG antibody associated demyelinating disease (MOGAD) is a newly described autoimmune disorder that presents with monophasic or multiphasic demyelination in children. We report a case of MOGAD that was refractory to current treatment algorithms and required rapid escalation of immunotherapy to achieve disease control. This case helps to further expand the phenotype of MOGAD and emphasizes the need to consider MOGAD in patients presenting with focal neurologic deficits, altered mental status, and/or seizures.
髓鞘少突胶质细胞糖蛋白（MOG）抗体相关脱髓鞘疾病（MOGAD）是一种新描述的自身免疫性疾病，在儿童中表现为单相或多相脱髓鞘。我们报告一例MOGAD，对当前的治疗方案无效，需要迅速加强免疫治疗以控制疾病。该病例有助于进一步拓展MOGAD的表型，并强调对于出现局灶性神经功能缺损、精神状态改变和/或癫痫发作的患者，需要考虑MOGAD的可能性。
