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二尖瓣手术治疗功能性二尖瓣反流:预测二尖瓣反流复发和中期结果。

Mitral valve surgery for atrial functional mitral regurgitation: predicting recurrent mitral regurgitation and mid-term outcome.

机构信息

Department of Cardiovascular Surgery, National Cerebral and Cardiovascular Center, 6-1 Kishibe-Shinmachi, Suita, Osaka, 564-8565, Japan.

出版信息

Gen Thorac Cardiovasc Surg. 2022 Sep;70(9):761-769. doi: 10.1007/s11748-022-01793-8. Epub 2022 Mar 3.

Abstract

OBJECTIVES

This study aimed to elucidate the mid-term outcomes and risk factors for recurrent mitral regurgitation after mitral valve (MV) surgery for atrial functional mitral regurgitation (AFMR).

METHODS AND RESULTS

We retrospectively analyzed data of 50 consecutive patients (median age 74 years; 29 men) who underwent mitral valve surgery for AFMR between January 2001 and January 2019. Mean atrial fibrillation duration was 12 years. During the follow-up period of 4.6 ± 4.4 years, 5 cardiac-related deaths were identified. Five- and 10-year freedom from cardiac-related death rate for all patients was 88.4% and 78.6%. In total, 42 patients underwent MV repair with mitral annuloplasty and 8 underwent MV replacement. Five- and 10-year freedom from cardiac-related death rate in patients who underwent MV repair was 93.1% and 82.7%, which was better than MV replacement (log rank p = 0.04). During the follow-up period, MR recurrence rate was 16.8% at 5 and 10 years for the patients who underwent MV repair. Univariate analysis showed that partial band annuloplasty and preoperative elevated left ventricular end-systolic volume index were risk factors for recurrent MR after MV repair. Multivariate analysis identified partial band annuloplasty as the independent predictor for recurrent MR during long-term follow-up after MV repair for AFMR.

CONCLUSION

Patients who underwent MV repair for AFMR could have an acceptable mid-term outcome. However, MVR might not improve the mid-term outcome in patients with AFMR. The use of partial bands for mitral annuloplasty would not be recommended in terms of recurrent MR mid-term.

摘要

目的

本研究旨在阐明因心房功能性二尖瓣反流(AFMR)而行二尖瓣(MV)手术后二尖瓣反流(MR)复发的中期结果和危险因素。

方法和结果

我们回顾性分析了 2001 年 1 月至 2019 年 1 月期间因 AFMR 而行 MV 手术的 50 例连续患者(中位年龄 74 岁;29 名男性)的数据。平均房颤持续时间为 12 年。在 4.6±4.4 年的随访期间,确定了 5 例与心脏相关的死亡病例。所有患者的 5 年和 10 年免于与心脏相关的死亡率分别为 88.4%和 78.6%。共有 42 例患者接受 MV 修复术伴二尖瓣环成形术,8 例患者接受 MV 置换术。MV 修复患者的 5 年和 10 年免于与心脏相关的死亡率分别为 93.1%和 82.7%,优于 MV 置换术(对数秩检验,p=0.04)。在随访期间,MV 修复患者的 MR 复发率在 5 年和 10 年时分别为 16.8%。单因素分析显示,部分瓣环成形术和术前左心室收缩末期容积指数升高是 MV 修复后 MR 复发的危险因素。多因素分析确定部分瓣环成形术是 MV 修复治疗 AFMR 后长期随访中 MR 复发的独立预测因素。

结论

因 AFMR 而行 MV 修复的患者可获得可接受的中期结果。然而,MVR 可能无法改善 AFMR 患者的中期结果。就中期 MR 而言,不建议使用部分瓣环成形术。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fea0/9371988/753fa5d2d723/11748_2022_1793_Fig1_HTML.jpg

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