Department of Normal Anatomy, the Ludwik Rydygier Collegium Medicum in Bydgoszcz, the Nicolaus Copernicus University in Torun, Poland.
Folia Morphol (Warsz). 2023;82(2):307-314. doi: 10.5603/FM.a2022.0020. Epub 2022 Mar 3.
Detailed morphometric data concentrating on the development of primary ossification centres in human fetuses is critical for the early detection of developmental defects. Thus, an understanding of the growth and development of the parietal bone is crucial in assessing both the normal and pathological development of the calvaria.
The size of the parietal primary ossification centre in 37 spontaneously aborted human fetuses of both sexes (16 males and 21 females) aged 18-30 weeks was studied by means of computed tomography, digital-image analysis and statistics.
The numerical data of the parietal primary ossification centre in the human fetus displays neither sex nor laterality differences. With relation to fetal age in weeks, the parietal primary ossification centre grew in sagittal diameter according to the quadratic function: y = 16.322 + 0.0347 × (age)² ± 1.323 (R² = 0.96), in projection surface area according to the cubic function: y = 284.1895 + 0.051 × × (age)³ ± 0.490, while in both coronal diameter and volume according to the quartic functions: y = 21.746 + 0.000025 × (age)⁴ ± 1.256 and y = 296.984 + + 0.001 × (age)⁴, respectively.
The obtained morphometric data of the parietal primary ossification centre may be considered age-specific references, and so may contribute to the estimation of gestational ages and be useful in the diagnostics of congenital cranial defects.
详细的形态计量学数据集中在人类胎儿的初级骨化中心的发育上，对于发育缺陷的早期检测至关重要。因此，了解顶骨的生长和发育对于评估颅骨的正常和病理发育都至关重要。
通过计算机断层扫描、数字图像分析和统计学方法，研究了 37 名 18-30 周龄的自发性流产男女胎儿（16 名男性和 21 名女性）顶骨初级骨化中心的大小。
胎儿顶骨初级骨化中心的数值数据既无性别差异，也无侧别差异。相对于胎儿的周龄，顶骨初级骨化中心的矢状径生长符合二次函数：y = 16.322 + 0.0347 × (age)² ± 1.323 (R² = 0.96)，在投影表面积上符合三次函数：y = 284.1895 + 0.051 × (age)³ ± 0.490，而在冠状直径和体积上则分别符合四次函数：y = 21.746 + 0.000025 × (age)⁴ ± 1.256 和 y = 296.984 + + 0.001 × (age)⁴。
获得的顶骨初级骨化中心的形态计量学数据可以被认为是特定年龄的参考值，有助于估计胎龄，并在先天性颅面缺陷的诊断中具有重要作用。
