Baumgart Mariusz, Wiśniewski Marcin, Grzonkowska Magdalena, Badura Mateusz, Szpinda Michał, Pawlak-Osińska Katarzyna
Department of Normal Anatomy, The Ludwik Rydygier Collegium Medicum in Bydgoszcz, The Nicolaus Copernicus University in Toruń, Toruń, Poland.
Department of Otolaryngology and Oncology, The Ludwik Rydygier Collegium Medicum in Bydgoszcz, The Nicolaus Copernicus University in Toruń, Toruń, Poland.
Surg Radiol Anat. 2019 Mar;41(3):297-305. doi: 10.1007/s00276-018-2147-5. Epub 2018 Dec 12.
Precise morphometric data on the development of ossification centers in human fetuses may be useful in the early detection of skeletal dysplasias associated with delayed ossification center development and mineralization. The present study was performed to quantitatively examine the primary ossification center of the fibular shaft with respect to its linear, planar and volumetric parameters.
Using methods of CT, digital-image analysis (Osirix 3.9 MD) and statistics (Student's t-test, Shapiro-Wilk, Fisher's test, Tukey's test, Kruskal-Wallis test, regression analysis), the size of the primary ossification center of the fibular shaft in 47 spontaneously aborted human fetuses (25 ♂ and 22 ♀) aged 17-30 weeks was studied. In each fetus, the assessment of linear dimensions (length, transverse diameters for: proximal end, middle part and distal end), projection surface area and volume of the fibular shaft ossification center was carried out.
With no sex and laterality differences, the best fit growth dynamics for the primary ossification center of the fibular shaft was modelled by the following functions: y = - 13.241 + 1.567 × age ± 1.556 (R = 0.94) for its length, y = - 0.091 + 0.063 × age ± 0.073 (R = 0.92) for its proximal transverse diameter, y = - 1.201 + 0.717 × ln(age) ± 0.054 (R = 0.83) for its middle transverse diameter, y = - 2.956 + 1.532 × ln(age) ± 0.090 (R = 0.89) for its distal transverse diameter, y = - 69.038 + 4.699 × age ± 4.055 (R = 0.95) for its projection surface area, and y = - 126.374 + 9.462 × age ± 8.845 (R = 0.94) for its volume.
The ossification center in the fibular shaft follows linear functions with respect to its length, proximal transverse diameter, projection surface area and volume, and natural logarithmic functions with respect to its middle and distal transverse diameters. The obtained morphometric data of the fibular shaft ossification center is considered normative for their respective prenatal weeks and may be of relevance in both the estimation of fetal age and the ultrasound diagnostics of congenital defects.
关于人类胎儿骨化中心发育的精确形态计量学数据可能有助于早期检测与骨化中心发育和矿化延迟相关的骨骼发育异常。本研究旨在定量检查腓骨干的初级骨化中心的线性、平面和体积参数。
采用CT、数字图像分析（Osirix 3.9 MD）和统计学方法（学生t检验、Shapiro-Wilk检验、Fisher检验、Tukey检验、Kruskal-Wallis检验、回归分析），研究了47例17至30周自然流产的人类胎儿（25例男性和22例女性）腓骨干初级骨化中心的大小。对每个胎儿的腓骨干骨化中心进行线性尺寸（长度、近端、中部和远端的横向直径）、投影表面积和体积的评估。
在无性别和左右侧差异的情况下，腓骨干初级骨化中心的最佳拟合生长动力学由以下函数建模：长度为y = - 13.241 + 1.567×年龄±1.556（R = 0.94）；近端横向直径为y = - 0.091 + 0.063×年龄±0.073（R = 0.92）；中部横向直径为y = - 1.201 + 0.717×ln(年龄)±0.054（R = 0.83）；远端横向直径为y = - 2.956 + 1.532×ln(年龄)±0.090（R = 0.89）；投影表面积为y = - 69.038 + 4.699×年龄±4.055（R = 0.95）；体积为y = - 126.374 + 9.462×年龄±8.845（R = 0.94）。
腓骨干的骨化中心在长度、近端横向直径、投影表面积和体积方面遵循线性函数，在中部和远端横向直径方面遵循自然对数函数。所获得的腓骨干骨化中心的形态计量学数据被认为对于其各自的孕周是规范的，并且可能在估计胎儿年龄和先天性缺陷的超声诊断中具有相关性。
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