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脑膜炎奈瑟菌 B 群疾病负担与预防专家共识会议纪要

Proceedings of the Expert Consensus Group meeting on meningococcal serogroup B disease burden and prevention in India.

机构信息

Pediatrics, ESI-PGIMSR & Model Hospital, New Delhi, India.

Pediatrics, Nemcare Superspeciality Hospital, Bhangagarh, Guwahati, and RIGPA Children's Clinic, Guwahati, India.

出版信息

Hum Vaccin Immunother. 2022 Dec 31;18(1):2026712. doi: 10.1080/21645515.2022.2026712. Epub 2022 Mar 3.

Abstract

Meningococcal disease is highly transmissible, life-threatening and leaves significant sequelae in survivors. Every year, India, which has a plethora of risk factors for meningococcal disease, reports around 3000 endemic cases. However, the overall disease burden and serogroup distribution are unknown, creating a setting of general disease negligence and unawareness. Vaccination with quadrivalent meningococcal conjugate vaccine A, C, W, and Y is only recommended for high-risk children, and there is no overall guidance for meningococcal serogroup B (MenB) vaccination. MenB vaccines, which recently have been licensed in many countries but not in India, have significantly aided the fight against meningococcal disease. However, these MenB vaccines are not available in India. An Expert Consensus Group meeting was held with leading meningococcal disease experts to better understand the current disease epidemiology, particularly serogroup B, the prevalence gaps, and feasible ways to bridge them. The proceedings are presented in this paper.

摘要

脑膜炎球菌病具有高度传染性,危及生命,并在幸存者中留下严重的后遗症。印度有大量脑膜炎球菌病的危险因素,每年报告约 3000 例地方性病例。然而,总体疾病负担和血清型分布尚不清楚,导致普遍存在疾病忽视和意识不足的情况。接种四价脑膜炎球菌结合疫苗 A、C、W 和 Y 仅推荐用于高危儿童,而对于脑膜炎球菌 B 血清型(MenB)疫苗接种没有总体指导。最近在许多国家获得许可但尚未在印度获得许可的 MenB 疫苗在对抗脑膜炎球菌病方面发挥了重要作用。然而,这些 MenB 疫苗在印度不可用。召开了一个专家共识小组会议,邀请了脑膜炎球菌病领域的主要专家参加,以更好地了解当前的疾病流行病学,特别是血清型 B、流行差距以及弥合这些差距的可行方法。本文介绍了会议的进展情况。

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