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实施拉丁美洲和加勒比区域 COVID-19 基因组监测区域网络。

Implementation of a COVID-19 Genomic Surveillance Regional Network for Latin America and Caribbean region.

机构信息

Health Emergencies Department, Pan American Health Organization, Washington, DC, United States of America.

Laboratorio de Virus Respiratorio, Fundação Oswaldo Cruz, Rio de Janeiro, RJ, Brazil.

出版信息

PLoS One. 2022 Mar 3;17(3):e0252526. doi: 10.1371/journal.pone.0252526. eCollection 2022.

Abstract

The timely release of SARS-CoV-2 first genomic sequences allowed the identification of the etiologic agent and development of diagnostic protocols. Genomic sequencing was a crucial step in generating data for driving laboratory response and detections of SARS-CoV-2 since the start of the COVID-19 pandemic. Because of all the progression and achievements that timely release of genetic sequence data represents in the public health response, the Pan American Health Organization (PAHO) in collaboration with countries' public health laboratories, started implementation of a network for strengthening the Latin America and Caribbean (LAC) region on timely generation of SARS-CoV-2 genomic data. Here we describe the implementation of the COVID-19 Genomic Surveillance Regional Network in the Americas region during the beginning of the pandemic. The establishment of this network has strengthened laboratory response capacity at the country level, as well as facilitated timely release of SARS-CoV-2 genomic information to be used to complement the multiple response strategies for COVID-19 pandemic mitigation. As genomic epidemiology is useful for guiding public health decisions on outbreak and response, we also analysed the first SARS-CoV-2 genomic sequence data from countries of the Latin America and Caribbean Region.

摘要

及时发布 SARS-CoV-2 的首个基因组序列,有助于鉴定病原体并开发诊断方案。自 COVID-19 大流行开始以来,基因组测序是为推动实验室应对和 SARS-CoV-2 检测生成数据的关键步骤。由于及时发布遗传序列数据在公共卫生应对方面取得了所有进展和成就,泛美卫生组织(PAHO)与各国公共卫生实验室合作,开始实施一个网络,以加强拉丁美洲和加勒比地区(LAC)及时生成 SARS-CoV-2 基因组数据的能力。在此,我们描述了在大流行初期在美洲地区实施 COVID-19 基因组监测区域网络的情况。该网络的建立加强了国家一级的实验室应对能力,并促进了及时发布 SARS-CoV-2 基因组信息,以补充 COVID-19 大流行缓解的多种应对策略。由于基因组流行病学有助于指导有关疫情和应对的公共卫生决策,我们还分析了来自拉丁美洲和加勒比地区国家的首批 SARS-CoV-2 基因组序列数据。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8fdd/8893691/7fb23115cabf/pone.0252526.g001.jpg

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