Enhancing demethylation-induced differentiation in IDH-mutant glioma.
作者信息
Miller Julie J, Cahill Daniel P, Arrillaga-Romany Isabel
机构信息
Center for Neuro-Oncology, Department of Neurology, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, USA.
Translational Neuro-Oncology Laboratory, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, USA.
出版信息
Neuro Oncol. 2022 May 4;24(5):724-725. doi: 10.1093/neuonc/noac056.
Abstract
摘要
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本文引用的文献
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Evaluation of a DNA demethylating agent in combination with all-trans retinoic acid for IDH1-mutant gliomas.评价一种去甲基化药物联合全反式维甲酸治疗 IDH1 突变型脑胶质瘤。
Neuro Oncol. 2022 May 4;24(5):711-723. doi: 10.1093/neuonc/noab263.
2
Demethylation and epigenetic modification with 5-azacytidine reduces IDH1 mutant glioma growth in combination with temozolomide.5-氮杂胞苷去甲基化和表观遗传修饰联合替莫唑胺降低 IDH1 突变型脑胶质瘤的生长。
Neuro Oncol. 2019 Feb 14;21(2):189-200. doi: 10.1093/neuonc/noy146.
3
Efficient induction of differentiation and growth inhibition in IDH1 mutant glioma cells by the DNMT Inhibitor Decitabine.DNA甲基转移酶抑制剂地西他滨对异柠檬酸脱氢酶1（IDH1）突变型胶质瘤细胞分化的高效诱导及生长抑制作用
Oncotarget. 2013 Oct;4(10):1729-36. doi: 10.18632/oncotarget.1412.
4
5-azacytidine reduces methylation, promotes differentiation and induces tumor regression in a patient-derived IDH1 mutant glioma xenograft.5-氮杂胞苷可降低甲基化水平，促进分化，并在患者来源的异柠檬酸脱氢酶1（IDH1）突变型神经胶质瘤异种移植模型中诱导肿瘤消退。
Oncotarget. 2013 Oct;4(10):1737-47. doi: 10.18632/oncotarget.1408.
5
IDH mutation impairs histone demethylation and results in a block to cell differentiation.IDH 突变会损害组蛋白去甲基化，导致细胞分化受阻。
Nature. 2012 Feb 15;483(7390):474-8. doi: 10.1038/nature10860.
6
IDH1 mutation is sufficient to establish the glioma hypermethylator phenotype.IDH1 突变足以建立起胶质瘤高甲基化表型。
Nature. 2012 Feb 15;483(7390):479-83. doi: 10.1038/nature10866.
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Identification of a CpG island methylator phenotype that defines a distinct subgroup of glioma.鉴定出一种 CpG 岛甲基化表型，它定义了神经胶质瘤的一个独特亚群。
Cancer Cell. 2010 May 18;17(5):510-22. doi: 10.1016/j.ccr.2010.03.017. Epub 2010 Apr 15.
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