Siwik Chelsea J, Cash Elizabeth, Sephton Sandra E
Osher Center for Integrative Medicine, University of California, San Francisco, CA, USA.
Department of Otolaryngology-Head and Neck Surgery and Communicative Disorders, University of Louisville School of Medicine, Louisville, KY, USA.
Psychol Health. 2023 Nov-Dec;38(12):1649-1664. doi: 10.1080/08870446.2022.2040500. Epub 2022 Mar 3.
To examine the association between depressive symptoms, leukocyte telomere length-a marker of cellular ageing, and survival amongst lung cancer patients.
Patients with non-small cell lung cancer were recruited from a university-affiliated cancer center clinic.
Patients ( = 67) reported on depressive symptoms and provided a blood sample for leukocyte telomere length assessment at baseline and at a 3-month follow-up. Survival status was tracked over 3 years.
Age at diagnosis and depressive symptoms, as measured by the CES-D, were associated with shorter leukocyte telomere length ( < .05), although only age at diagnosis contributed statistical significance to the model. Depressive symptoms predicted shorter survival from date of diagnosis ( < .01). Patients who reported experiencing clinically meaningful levels of depressive symptoms (CES-D scores ≥ 16) demonstrated shorter survival than those who reported sub-clinical levels of depressive symptoms ( < .05). Leukocyte telomere length did not emerge as a predictor of shorter survival.
Clinically meaningful levels of depressive symptoms are associated with shorter survival amongst lung cancer patients. These findings support the on-going efforts to screen all cancer patients for low mood and to investigate mechanisms linking depressive symptoms and shorter survival in cancer contexts.
研究肺癌患者的抑郁症状、白细胞端粒长度（细胞衰老的一个标志物）与生存率之间的关联。
从一所大学附属医院的癌症中心诊所招募非小细胞肺癌患者。
67名患者报告了抑郁症状，并在基线期和3个月随访时提供血样用于白细胞端粒长度评估。对其3年的生存状况进行跟踪。
通过流调中心抑郁量表（CES-D）测得的诊断时年龄和抑郁症状与较短的白细胞端粒长度相关（P<0.05），不过只有诊断时年龄对模型具有统计学意义。抑郁症状预示着自诊断之日起生存期较短（P<0.01）。报告有临床显著水平抑郁症状（CES-D评分≥16）的患者比报告有亚临床水平抑郁症状的患者生存期更短（P<0.05）。白细胞端粒长度并未成为生存期较短的预测因素。
临床显著水平的抑郁症状与肺癌患者较短的生存期相关。这些发现支持持续努力对所有癌症患者进行情绪低落筛查，并研究在癌症背景下将抑郁症状与较短生存期联系起来的机制。
