Foshan Stomatological Hospital, School of Medicine, Foshan University, Foshan, Guangdong, China.
Department of Oral and Maxillofacial Surgery, NanFang Hospital, Southern Medical University, Guangzhou, China.
Bioengineered. 2022 Mar;13(3):6371-6382. doi: 10.1080/21655979.2022.2040768.
Emerging studies indicate that long non-coding RNAs play important roles in oral squamous cell carcinoma (OSCC). However, the function of the majority of long non-coding RNAs is still unclear. Recently, LINC00472 has been reported to play crucial roles in multiple cancers. However, the role of LINC00472 in oral squamous cell carcinoma (OSCC) is still not clear. This study found that LncRNA LINC00472 was significantly down-regulated in several squamous cell carcinoma cancer tissues and OSCC cell lines. Over-expression of LINC00472 in OSCC cells inhibited OSCC progression and alleviated OSCC immune responses. Additionally, we confirmed that LINC00472 functioned as an hsa-miR-4311 sponge and regulated the expression of GNG7 (guanine nucleotide-binding protein, gamma 7). Also, we found that LINC00472 over-expression could suppress xenograft tumor growth in . Our study provides evidence that LINC00472 plays an essential role in inhibiting oral squamous cell carcinoma progression and affecting immune responses by directly binding to hsa-miR-4311 to regulate the expression of GNG7 positively.
新兴研究表明，长非编码 RNA 在口腔鳞状细胞癌（OSCC）中发挥重要作用。然而，大多数长非编码 RNA 的功能仍不清楚。最近，LINC00472 已被报道在多种癌症中发挥关键作用。然而，LINC00472 在口腔鳞状细胞癌（OSCC）中的作用尚不清楚。本研究发现，LncRNA LINC00472 在几种鳞状细胞癌组织和 OSCC 细胞系中显著下调。OSCC 细胞中 LINC00472 的过表达抑制了 OSCC 的进展并减轻了 OSCC 的免疫反应。此外，我们证实 LINC00472 作为 hsa-miR-4311 的海绵并调节 GNG7（鸟嘌呤核苷酸结合蛋白，γ 7）的表达。此外，我们发现 LINC00472 的过表达可以抑制异种移植肿瘤在. 中的生长。我们的研究提供了证据表明，LINC00472 通过直接与 hsa-miR-4311 结合正向调节 GNG7 的表达，在抑制口腔鳞状细胞癌进展和影响免疫反应中发挥重要作用。
