Department of Oral and Craniomaxillofacial Surgery, Eppendorf University Hospital, University of Hamburg, Hamburg, Germany;
Department of Orthodontics, Eppendorf University Hospital, University of Hamburg, Hamburg, Germany.
In Vivo. 2022 Mar-Apr;36(2):1021-1029. doi: 10.21873/invivo.12797.
Noonan syndrome (NS) is a multigenic disorder with a highly variable phenotype. Cardiac disorders and a predisposition to neoplasm often require early medical attention. Central giant central lesions (CGCLs) of the jaws are part of the phenotype.
In a patient with genetically confirmed NS and multiple teeth loss presumably caused by CGCL, careful review of the medical history and radiographic findings made it probable that the cause of tooth loss was cervical root resorption (CRR) of the teeth following long-term orthodontic therapy.
CRR is a rare dental disease of unknown origin. However, association with prior orthodontic therapy is well documented. In NS, mandibular lesions can occur which, at first glance, might lead the examiner to assume that it is a CGCL, but on closer analysis, obviously are of non-tumorous origin and should be assessed as coincidental. The report adds relevant information to orthodontic treatment of NS patients.
努南综合征（NS）是一种多基因疾病，具有高度可变的表型。心脏疾病和肿瘤易感性通常需要早期的医疗关注。颌骨中央巨中央病变（CGCLs）是表型的一部分。
在一名经基因证实患有 NS 的患者中，由于 CGCL 导致多颗牙齿缺失，仔细回顾病史和影像学检查结果，表明牙齿缺失的原因很可能是长期正畸治疗后牙齿的颈根吸收（CRR）。
CRR 是一种病因不明的罕见牙科疾病。然而，与先前的正畸治疗有关的情况已有充分记录。在 NS 中，下颌病变可能会发生，乍一看，可能会导致检查者认为这是 CGCL，但经过更仔细的分析，显然是肿瘤样起源，应被评估为偶然。该报告为 NS 患者的正畸治疗提供了相关信息。
