Anderson D E, Gomez-Sanchez C, Dietz J R
Am J Physiol. 1986 Jul;251(1 Pt 2):R181-6. doi: 10.1152/ajpregu.1986.251.1.R181.
Plasma renin activity (PRA) and plasma aldosterone concentrations (PAC) of 12 intact chronically instrumented dogs were measured at midday after 1) 7-12 days of normal sodium intake and no behavioral stress, 2) 7-12 days of continuous saline infusion (1.34 l/day) only, and/or 3) 7-12 days of saline infusion and avoidance-conditioning sessions. The saline infusion procedure did not significantly change arterial pressure or heart rate relative to base line but was associated with a consistent decrease in PRA (-0.90 +/- 0.38 ng angiotensin I . ml-1 . h-1) and PAC (-3.6 +/- 1.1 ng/dl). The combination of saline infusion and avoidance conditioning resulted in significant elevations in arterial pressure, but, again, both PRA (-1.46 +/- 0.16 ng angiotensin I . ml-1 . h-1) and PAC (-3.7 +/- 1.1 ng/dl) were significantly decreased. These results show that high sodium intake decreased aldosterone via suppression of renin release but do not rule out a possible hypertensinogenic role for stress-induced adrenocorticotrophic hormone-sensitive corticoids.
对12只长期植入仪器的未阉割犬，在中午测量其血浆肾素活性（PRA）和血浆醛固酮浓度（PAC），测量条件如下：1）正常钠摄入且无行为应激7 - 12天；2）仅连续输注生理盐水（1.34升/天）7 - 12天；和/或3）输注生理盐水并进行回避条件训练7 - 12天。相对于基线，输注生理盐水过程未显著改变动脉压或心率，但与PRA（-0.90±0.38纳克血管紧张素I·毫升⁻¹·小时⁻¹）和PAC（-3.6±1.1纳克/分升）持续下降有关。输注生理盐水与回避条件训练相结合导致动脉压显著升高，但PRA（-1.46±0.16纳克血管紧张素I·毫升⁻¹·小时⁻¹）和PAC（-3.7±1.1纳克/分升）再次显著降低。这些结果表明，高钠摄入通过抑制肾素释放降低醛固酮，但不排除应激诱导的促肾上腺皮质激素敏感性皮质激素可能具有的致高血压作用。
