Zhang Tao, Gao Guangqi, Sakandar Hafiz Arbab, Kwok Lai-Yu, Sun Zhihong
Key Laboratory of Dairy Biotechnology and Engineering, Ministry of Education, Inner Mongolia Agricultural University, Hohhot, China.
Key Laboratory of Dairy Products Processing, Ministry of Agriculture and Rural Affairs, Inner Mongolia Agricultural University, Hohhot, China.
Front Nutr. 2022 Feb 15;9:814269. doi: 10.3389/fnut.2022.814269. eCollection 2022.
Pancreatic-related disorders such as pancreatitis, pancreatic cancer, and type 1 diabetes mellitus (T1DM) impose a substantial challenge to human health and wellbeing. Even though our understanding of the initiation and progression of pancreatic diseases has broadened over time, no effective therapeutics is yet available for these disorders. Mounting evidence suggests that gut dysbiosis is closely related to human health and disease, and pancreatic diseases are no exception. Now much effort is under way to explore the correlation and eventually potential causation between the gut microbiome and the course of pancreatic diseases, as well as to develop novel preventive and/or therapeutic strategies of targeted microbiome modulation by probiotics, prebiotics, synbiotics, postbiotics, and fecal microbiota transplantation (FMT) for these multifactorial disorders. Attempts to dissect the intestinal microbial landscape and its metabolic profile might enable deep insight into a holistic picture of these complex conditions. This article aims to review the subtle yet intimate nexus loop between the gut microbiome and pancreatic diseases, with a particular focus on current evidence supporting the feasibility of preventing and controlling pancreatic diseases microbiome-based therapeutics and therapies.
胰腺炎、胰腺癌和1型糖尿病（T1DM）等胰腺相关疾病对人类健康和福祉构成了重大挑战。尽管随着时间的推移，我们对胰腺疾病的发生和发展的理解有所拓宽，但针对这些疾病仍没有有效的治疗方法。越来越多的证据表明，肠道微生物群失调与人类健康和疾病密切相关，胰腺疾病也不例外。目前正在进行大量研究，以探索肠道微生物群与胰腺疾病病程之间的相关性以及最终可能的因果关系，并开发通过益生菌、益生元、合生元、后生元以及粪便微生物群移植（FMT）对微生物群进行靶向调节的新型预防和/或治疗策略，用于治疗这些多因素疾病。剖析肠道微生物格局及其代谢谱的尝试可能有助于深入了解这些复杂病症的整体情况。本文旨在综述肠道微生物群与胰腺疾病之间微妙而紧密的联系，特别关注支持基于微生物群的治疗方法预防和控制胰腺疾病可行性的现有证据。
