Sakai Yuki, Larsen Jeanette Brun, Reitan Solveig Klæbo
UMR 1253, iBrain, Université de Tours, Inserm, Tours, France.
Norwegian University of Science and Technology, Faculty of Medicine and Health Science, Department of Mental Health, Trondheim, Norway.
Heliyon. 2022 Feb 19;8(2):e08992. doi: 10.1016/j.heliyon.2022.e08992. eCollection 2022 Feb.
Increased levels of high-sensitivity C-reactive protein (hsCRP) is associated with several psychiatric disorders. Demographic factors such as age and gender might affect this association, but the results are conflicting. The aim of this study was to explore a relationship between age, gender and hsCRP in an acute psychiatric inpatient population. We included 484 patients admitted to an acute psychiatric ward. Based on age distribution percentiles (25%, 50% and 75 %), we categorized patients into three age groups; ≦31 years old, 31-47 years old and ≧ 48 years old. Differences in serum levels of hsCRP between the age groups were assessed in the total sample, within males and females, and within diagnostic groups. There were significant differences in hsCRP across age groups. The effect was stronger in males than females. The significant differences between age groups were kept among patients with substance use disorders and bipolar disorders, but not among schizophrenia spectrum disorders, unipolar depression, neurotic disorders and personality disorders. Our findings suggest that the previously known association between age and hsCRP is present within an acute psychiatric population. However, this association was not found for all psychiatric diagnoses.
高敏C反应蛋白（hsCRP）水平升高与多种精神疾病相关。年龄和性别等人口统计学因素可能会影响这种关联，但结果相互矛盾。本研究的目的是探讨急性精神科住院患者中年龄、性别与hsCRP之间的关系。我们纳入了484名入住急性精神科病房的患者。根据年龄分布百分位数（25%、50%和75%），我们将患者分为三个年龄组：≤31岁、31 - 47岁和≥48岁。在总样本、男性和女性以及诊断组内评估年龄组之间hsCRP血清水平的差异。各年龄组之间的hsCRP存在显著差异。男性的这种效应比女性更强。年龄组之间的显著差异在物质使用障碍和双相情感障碍患者中存在，但在精神分裂症谱系障碍、单相抑郁症、神经症和人格障碍患者中不存在。我们的研究结果表明，年龄与hsCRP之间先前已知的关联在急性精神科人群中存在。然而，并非所有精神科诊断都存在这种关联。
