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儿童眼周皮下环状肉芽肿:一例报告

Periocular subcutaneous granuloma annulare in a child: A case report.

作者信息

AlOqab Aysha Waheed, Butt Sohail A, AlHammad Fatimah Abbas

机构信息

Oculoplasty, Dhahran Eye Specialist Hospital, Dhahran, Saudi Arabia.

Ophthalmology, Bahrain Defence Force Hospital, Riffa, Bahrain.

出版信息

Am J Ophthalmol Case Rep. 2022 Jan 24;25:101317. doi: 10.1016/j.ajoc.2022.101317. eCollection 2022 Mar.

Abstract

PURPOSE

We describe a rare case of annular granuloma involving the eyelid of a child, a 6-year-old male, who presented with multiple subcutaneous nodular lesions involving the upper eyelid of the right eye.

OBSERVATIONS

The slit-lamp examination of the eye was normal. Extra-ocular examination showed a lesion on the dorsal aspect of the right foot, which was resistant to treatment with topical corticosteroids. He underwent surgical excision of the eyelid nodules under general anesthesia. Histopathology with immunohistochemical staining of the excisional biopsy confirmed the diagnosis of annular granuloma, with positive Vimentin and CD68 stains in many palisading histiocytic cells, while Factor VIIIa, S100, and CD1a were negative. Tuberculosis was ruled out by negative Ziehl-Neelsen staining for acid-fast bacilli.

CONCLUSIONS AND IMPORTANCE

This idiopathic granulomatous condition proved to be a benign, self-limiting cutaneous disease that can regress spontaneously. It affects the skin of the foot in more than 70% of all patients; however, involvement of the eyelid is extremely rare. We report this case to highlight such a rare entity and increase awareness regarding this dermatological condition among ophthalmologists.

摘要

目的

我们描述了一例罕见的环状肉芽肿累及一名6岁男性儿童眼睑的病例,该患儿右眼上睑出现多个皮下结节性病变。

观察结果

眼部裂隙灯检查正常。眼外检查发现右脚背有一处病变,局部使用皮质类固醇治疗无效。他在全身麻醉下接受了眼睑结节的手术切除。切除活检的组织病理学检查及免疫组化染色确诊为环状肉芽肿,许多栅栏状组织细胞中波形蛋白和CD68染色呈阳性,而第八因子相关抗原、S100和CD1a呈阴性。抗酸杆菌的齐-尼氏染色阴性排除了结核病。

结论及重要性

这种特发性肉芽肿性疾病被证明是一种良性、自限性皮肤病,可自发消退。超过70%的患者足部皮肤会受到影响;然而,累及眼睑极为罕见。我们报告此病例以突出这种罕见情况,并提高眼科医生对这种皮肤病的认识。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b537/8859739/79b79269efc7/gr1.jpg

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