[H-2系统中合成巨噬细胞移动抑制因子的T细胞的特征]

[Characteristics of T-cells synthesizing macrophage migration inhibition factor in an H-2 system].

作者信息

Suslov A P, Brondz B D, Egorova S G

出版信息

Biull Eksp Biol Med. 1978 Jun;85(6):701-4.

Abstract

Migration inhibition factor (MIF) was found to be produced by T-cells rather than B-cells as shown by the indirect macrophage migration inhibition test in the H-2 system performed with fractionated lymphocytes. MIF-producers appeared to be more sensitive than T-killer cells to the cytotoxic action of anti-theta-antibodies, plus complement. MIF synthesis by lymph node cells developed earlier after immunization than the cytotoxic activity of these cells. These findings indicated that T-cell subpopulation producing MIF differed from the cytotoxic T-lymphocytes.

摘要

通过在H-2系统中使用分离的淋巴细胞进行间接巨噬细胞迁移抑制试验表明，迁移抑制因子（MIF）是由T细胞而非B细胞产生的。MIF产生细胞似乎比T杀伤细胞对抗θ抗体加补体的细胞毒性作用更敏感。免疫后，淋巴结细胞的MIF合成比这些细胞的细胞毒性活性出现得更早。这些发现表明，产生MIF的T细胞亚群与细胞毒性T淋巴细胞不同。

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