慢性丙型肝炎患者亚临床颈动脉粥样硬化的风险。
The risk of subclinical carotid atherosclerosis in patients with chronic hepatitis C.
出版信息
Tunis Med. 2021;99(4):449-455.
INTRODUCTION
The role of hepatitis C virus in the pathogenesis of atherosclerotic disease has been suggested by several studies.
AIM
To assess the association between subclinical carotid atherosclerosis and chronic hepatitis C.
METHODS
40 patients infected with chronic hepatitis C and 40 control cases were evaluated by anthropometric and metabolic measurements. The risk of subclinical atherosclerosis was assessed by ultrasound measurement of carotid intima-media thickness. A high cardiovascular risk atherosclerosis was defined by carotid intima-media thickness > 75th percentile.
RESULTS
The carotid intima-media thickness and the prevalence of high cardiovascular risk atherosclerosis were significantly higher in the group infected with hepatitis C compared to the control group (0.68 VS 0.60, p=0.02) and (82.5% vs. 40%; 0.001) respectively. In multivariate studies, activity ≥ A2 and age> 40 years were the independent factors associated with the carotid intima-media thickness and hepatitis C was the only independent factor associated with high cardiovascular risk atherosclerosis (OR=4.81 CI at 95%: 1.6-14.42).
CONCLUSIONS
In our study, chronic hepatitis C was associated with a high risk of carotid atherosclerosis.
简介
几项研究表明，丙型肝炎病毒在动脉粥样硬化疾病的发病机制中起作用。
目的
评估亚临床颈动脉粥样硬化与慢性丙型肝炎之间的关系。
方法
评估 40 例慢性丙型肝炎感染患者和 40 例对照病例的人体测量和代谢测量。通过超声测量颈动脉内膜中层厚度评估亚临床动脉粥样硬化的风险。将颈动脉内膜中层厚度>75 百分位数定义为高心血管风险动脉粥样硬化。
结果
与对照组相比，丙型肝炎感染组的颈动脉内膜中层厚度和高心血管风险动脉粥样硬化的患病率显著更高（0.68 比 0.60，p=0.02）和（82.5%比 40%；0.001）。在多变量研究中，活动度≥A2 和年龄>40 岁是与颈动脉内膜中层厚度相关的独立因素，而丙型肝炎是与高心血管风险动脉粥样硬化相关的唯一独立因素（OR=4.81，95%置信区间：1.6-14.42）。
结论
在我们的研究中，慢性丙型肝炎与颈动脉粥样硬化的高风险相关。
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