DNA 连接酶和 PCNA：双环向下，封闭 DNA 断裂。
DNA ligase and PCNA: Double-ring down to seal a break in DNA.
机构信息
Department of Biochemistry, Molecular Biology and Biophysics, University of Minnesota, Minneapolis, MN 55455, USA; Institute for Molecular Virology, University of Minnesota, Minneapolis, MN 55455, USA; Masonic Cancer Center, University of Minnesota, Minneapolis, MN 55455, USA.
出版信息
Structure. 2022 Mar 3;30(3):324-326. doi: 10.1016/j.str.2022.02.008.
In this issue of Structure, Sverzhinsky et al. (2022) report structures of archaeal DNA ligase bound to the proliferating cell nuclear antigen (PCNA) sliding clamp and a nicked DNA substrate. The structures provide snapshots of ligation intermediates, which reveal a dynamic nature of the complex and explain how PCNA stimulates the DNA ligase activity.
在本期《结构》杂志中，Sverzhinsky 等人（2022 年）报道了与增殖细胞核抗原（PCNA）滑动夹和缺口 DNA 底物结合的古菌 DNA 连接酶的结构。这些结构提供了连接中间体的快照，揭示了复合物的动态性质，并解释了 PCNA 如何刺激 DNA 连接酶的活性。
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