释放陷阱：解聚酶 p97 如何从染色质中提取 PARP1。

Releasing the trap: How the segregase p97 extracts PARP1 from chromatin.

机构信息

Department of Biochemistry, Ludwig-Maximilians-University, 81377 Munich, Germany; Gene Center, Ludwig-Maximilians-University, 81377 Munich, Germany.

出版信息

Mol Cell. 2022 Mar 3;82(5):889-890. doi: 10.1016/j.molcel.2022.02.012.

DOI:10.1016/j.molcel.2022.02.012

PMID:35245455

Abstract

Krastev et al. (2022) identify a cellular mechanism that counteracts cytotoxic trapping of PARP1 induced by clinical PARP inhibitors. SUMO-targeted ubiquitylation of trapped PARP1 is shown to trigger the enzymes' extraction from chromatin by the p97 ATPase.

摘要

克拉斯特夫等人（2022 年）确定了一种细胞机制，该机制可以对抗临床 PARP 抑制剂诱导的 PARP1 细胞毒性捕获。研究表明，被捕获的 PARP1 的 SUMO 靶向泛素化会触发 p97 ATP 酶将其从染色质中提取出来。