Department of Biochemistry, Ludwig-Maximilians-University, 81377 Munich, Germany; Gene Center, Ludwig-Maximilians-University, 81377 Munich, Germany.
Department of Biochemistry, Ludwig-Maximilians-University, 81377 Munich, Germany; Gene Center, Ludwig-Maximilians-University, 81377 Munich, Germany.
Mol Cell. 2022 Mar 3;82(5):889-890. doi: 10.1016/j.molcel.2022.02.012.
Krastev et al. (2022) identify a cellular mechanism that counteracts cytotoxic trapping of PARP1 induced by clinical PARP inhibitors. SUMO-targeted ubiquitylation of trapped PARP1 is shown to trigger the enzymes' extraction from chromatin by the p97 ATPase.
克拉斯特夫等人（2022 年）确定了一种细胞机制，该机制可以对抗临床 PARP 抑制剂诱导的 PARP1 细胞毒性捕获。研究表明，被捕获的 PARP1 的 SUMO 靶向泛素化会触发 p97 ATP 酶将其从染色质中提取出来。
