Gonzalez Rodrigo J, von Andrian Ulrich H
Department of Immunology, Harvard Medical School, Boston, MA, USA; The Ragon Institute of MGH, MIT and Harvard, Cambridge, MA, USA.
Department of Immunology, Harvard Medical School, Boston, MA, USA; The Ragon Institute of MGH, MIT and Harvard, Cambridge, MA, USA.
Cell. 2022 Mar 3;185(5):759-761. doi: 10.1016/j.cell.2022.02.009.
Neutrophil recruitment from blood into tissues is a hallmark of inflammation and anti-microbial host defense. In this issue, De Giovanni et al. describe an unanticipated role for a serotonin metabolite, 5-HIAA, which is produced by activated platelets and mast cells and engages the orphan receptor, GPR35, to recruit neutrophils to inflamed tissues.
中性粒细胞从血液中募集到组织中是炎症和抗微生物宿主防御的一个标志。在本期杂志中，德乔瓦尼等人描述了血清素代谢产物5-羟吲哚乙酸（5-HIAA）的一个意想不到的作用，5-HIAA由活化的血小板和肥大细胞产生，并与孤儿受体GPR35结合，将中性粒细胞募集到炎症组织中。
