Kay N E, Raij L R
Blood Purif. 1986;4(1-3):120-9. doi: 10.1159/000169435.
Considerable work needs to be done in order to understand the immunosuppressive effect of 'uremia' and the lymphocyte changes induced by hemodialysis. For example, the lymphocyte population dynamics can be further defined using monoclonal antibodies specific for lymphocyte subgroups. In vitro assays are available for lymphokine detection (i.e. IL-1, IL-2 which are important for T cell function) and may be correlated with both the clinical state and overall immunobiological status of hemodialyzed patients. The possibility of specifically delineating the extent of the immune system dysfunction in renal failure patients (on or off dialysis) is at hand. With this knowledge it will be possible to manipulate their management so as to minimize function alterations.
为了理解“尿毒症”的免疫抑制作用以及血液透析引起的淋巴细胞变化，仍需开展大量工作。例如，可以使用针对淋巴细胞亚群的单克隆抗体进一步明确淋巴细胞群体动态。体外检测可用于检测淋巴因子（即对T细胞功能很重要的白细胞介素-1、白细胞介素-2），并且可能与血液透析患者的临床状态和整体免疫生物学状态相关。明确肾衰竭患者（透析或未透析）免疫系统功能障碍程度的可能性已近在眼前。有了这些知识，就有可能对他们的治疗进行调整，以尽量减少功能改变。
