通过在水中进行一锅串联绿色伪六组分反应无催化剂合成四氢二吡唑并吡啶。
Catalyst-free synthesis of tetrahydrodipyrazolopyridines via an one-pot tandem and green pseudo-six-component reaction in water.
作者信息
Keihanfar Mina, Mirjalili Bi Bi Fatemeh
机构信息
Department of Chemistry, College of Science, Yazd University, Yazd, Iran.
出版信息
BMC Chem. 2022 Mar 4;16(1):9. doi: 10.1186/s13065-022-00802-4.
BACKGROUND
A new, green and environmentally friendly protocol has been developed for the synthesis of tetrahydrodipyrazolopyridine derivatives. The structures of these products were determined in terms of melting point, FTIR, NMR and Mass spectroscopy.
RESULTS
The tetrahydrodipyrazolopyridine derivatives were synthesized in water through a catalyst-free pseudo-six-component reaction of hydrazine hydrate, ethyl acetoacetate, ammonium acetate and aldehyde at room temperature.
CONCLUSIONS
This novel procedure has some advantages such as aqueous media, high yield and simple work-up.
背景
已开发出一种用于合成四氢二吡唑并吡啶衍生物的新型绿色环保方案。这些产物的结构通过熔点、傅里叶变换红外光谱（FTIR）、核磁共振（NMR）和质谱进行测定。
结果
在室温下，通过水合肼、乙酰乙酸乙酯、乙酸铵和醛的无催化剂假六组分反应在水中合成了四氢二吡唑并吡啶衍生物。
结论
该新方法具有一些优点，如水相介质、高收率和后处理简单。
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