Cotton James A, Doyle Stephen R
Wellcome Sanger Institute, Wellcome Genome Campus, Hinxton, Cambridgeshire, CB10 1SA, UK.
Wellcome Sanger Institute, Wellcome Genome Campus, Hinxton, Cambridgeshire, CB10 1SA, UK.
Trends Parasitol. 2022 May;38(5):351-352. doi: 10.1016/j.pt.2022.02.006. Epub 2022 Mar 1.
The anthelmintic praziquantel (PZQ) is an essential tool in controlling schistosomiasis, so reports of reduced PZQ efficacy are of great public health concern. Le Clec'h et al. recently identified a gene responsible for PZQ resistance in experimentally selected resistant Schistosoma mansoni. The importance of this locus in natural infections remains to be established.
抗蠕虫药吡喹酮（PZQ）是控制血吸虫病的重要工具，因此吡喹酮疗效降低的报告引起了极大的公共卫生关注。勒克莱克等人最近在实验选择的抗性曼氏血吸虫中鉴定出一个与吡喹酮抗性相关的基因。该基因座在自然感染中的重要性仍有待确定。
