Gerasimov Iu V, Fridenshteĭn A Ia, Chaĭlakhian R K, Shishkova V V
Biull Eksp Biol Med. 1986 Jun;101(6):717-9.
The clonal nature of CFUf-derived fibroblast colonies was proved by chromosomal analysis of individual colonies and single-colony-derived fibroblast strains using mixed cell cultures from male and female rabbits. CFUf progeny, forming colonies composed of more than 10(3) cells was capable of 20-30 cell doublings during subsequent passages. When transplanted in diffusion chambers, single-colony-derived fibroblast strains formed bone and cartilage simultaneously. Thus, CFUf or part of them can be regarded as bone marrow osteogenic stem cells.
通过对来自雄性和雌性兔子的混合细胞培养物中的单个集落和单集落衍生的成纤维细胞系进行染色体分析，证明了CFUf衍生的成纤维细胞集落的克隆性质。形成由超过10(3)个细胞组成集落的CFUf后代在随后的传代过程中能够进行20 - 30次细胞倍增。当移植到扩散室中时，单集落衍生的成纤维细胞系同时形成骨和软骨。因此，CFUf或其中一部分可被视为骨髓成骨干细胞。
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