Department of Clinical Sciences, Cummings School of Veterinary Medicine at Tufts University, North Grafton, Massachusetts, USA.
Biostatistics, Epidemiology, and Research Design (BERD) Center, Tufts Medical Center, Boston, Massachusetts, USA.
Vet Ophthalmol. 2022 Jul;25(4):282-290. doi: 10.1111/vop.12982. Epub 2022 Mar 5.
To compare effects of latanoprost, a topical prostaglandin analogue (PGA) commonly used to treat glaucoma and lens instability in dogs, and latanoprostene bunod, a novel PGA with a nitric oxide-donating moiety, on intraocular pressure (IOP) and pupil diameter (PD).
Ten ophthalmologically normal Beagle dogs.
Dogs were treated twice a day for 5 days in a randomly selected eye with either latanoprost or latanoprostene bunod. After a 6-week washout period, dogs were treated with the opposite drug. IOP and PD were measured at treatment times, at midday on days 1 and 5, and for 6 days post-treatment.
Both drugs significantly decreased IOP and PD. At midday on day 5 of treatment, mean IOP in eyes treated with latanoprost was 4.5 mmHg lower than the fellow eye and 3.0 mmHg lower than the same eye at baseline, while mean IOP in eyes treated with latanoprostene bunod was 5.5 mmHg lower than the fellow eye and 3.6 mmHg lower than baseline. Mean PD was 0.94 mm in eyes treated with latanoprost and 0.76 mmHg in eyes treated with latanoprostene bunod. There was no significant difference between the two drugs for either parameter at that time point (p = .372 and .619, respectively, for IOP relative to control and to baseline; p = .076 for PD) or when analyzed longitudinally. Significant diurnal variation in PD was noted and may have implications for treatment of lens' instability.
Latanoprost and latanoprostene bunod produce similar IOP reduction and miosis in normal canine eyes.
比较常用于治疗青光眼和犬晶状体不稳定的局部前列腺素类似物（PGA）拉坦前列素和具有一氧化氮供体部分的新型 PGA 拉坦前列素烯醇，对眼压（IOP）和瞳孔直径（PD）的影响。
10 只眼科正常比格犬。
在随机选择的一只眼上，每天两次给犬治疗 5 天，用拉坦前列素或拉坦前列素烯醇治疗。经过 6 周的洗脱期后，犬用相反的药物治疗。在治疗时、第 1 天和第 5 天中午以及治疗后 6 天测量 IOP 和 PD。
两种药物均显著降低 IOP 和 PD。在治疗的第 5 天中午，用拉坦前列素治疗的眼睛的平均 IOP 比对侧眼低 4.5mmHg，比基线时低 3.0mmHg，而用拉坦前列素烯醇治疗的眼睛的平均 IOP 比对侧眼低 5.5mmHg，比基线时低 3.6mmHg。用拉坦前列素治疗的眼睛的平均 PD 为 0.94mm，用拉坦前列素烯醇治疗的眼睛的平均 PD 为 0.76mmHg。在该时间点，两种药物在这两个参数上均无显著差异（相对于对照和基线的 IOP 分别为 p =.372 和.619；PD 为 p =.076），或者进行纵向分析时也无显著差异。PD 存在明显的昼夜变化，这可能对视物不稳定的治疗有影响。
拉坦前列素和拉坦前列素烯醇在正常犬眼中产生相似的 IOP 降低和瞳孔缩小。
