Department of Pharmacology, Graduate School of Biomedical and Health Sciences, Hiroshima University, Japan; Department of Dental Anesthesiology, Graduate School of Biomedical and Health Sciences, Hiroshima University, Japan.
Department of Pharmacology, Graduate School of Biomedical and Health Sciences, Hiroshima University, Japan.
Behav Brain Res. 2022 May 3;425:113829. doi: 10.1016/j.bbr.2022.113829. Epub 2022 Mar 3.
Post-traumatic trigeminal neuropathy (PTTN) is a chronic sensory disorder that afflicts patients with nerve injury caused by orofacial and dental surgery or cervicofacial trauma. Currently, effective treatment strategies for PTTN are lacking, and patients treated with conventional drugs for PTTN experience adverse effects such as drowsiness and drug addiction. In the present study, we investigated whether mirogabalin, a novel gabapentinoid, could be an effective treatment for PTTN induced by distal infraorbital nerve chronic constriction injury (dIoN-CCI) in the mouse. Increased facial grooming time and hyper-responsiveness to acetone were observed in dIoN-CCI mice. These pain-related behaviors were attenuated by intraperitoneal injection of mirogabalin. In particular, mirogabalin significantly diminished the increase in facial grooming time. The analgesic effect of mirogabalin injection started 45 min after the injection and persisted for 6 h. Additionally, 10 mg/kg mirogabalin did not affect locomotor activity in the open field test, suggesting that it does not cause sedation. Together, the current findings suggest that mirogabalin could be a valuable therapeutic drug for PTTN following orofacial surgeries without sedative side effects.
创伤后三叉神经感觉根神经病（PTTN）是一种慢性感觉障碍，影响因口腔颌面和牙科手术或头颈部创伤导致神经损伤的患者。目前，PTTN 的有效治疗策略缺乏，接受 PTTN 常规药物治疗的患者会出现嗜睡和药物成瘾等不良反应。在本研究中，我们研究了新型加巴喷丁类药物米罗加巴林是否可有效治疗小鼠眶下神经远端慢性缩窄性损伤（dIoN-CCI）引起的 PTTN。dIoN-CCI 小鼠表现出面部梳理时间增加和对丙酮的超敏反应。腹腔注射米罗加巴林可减轻这些与疼痛相关的行为。特别是，米罗加巴林显著减少了面部梳理时间的增加。米罗加巴林注射后的镇痛作用在注射后 45 分钟开始，并持续 6 小时。此外，10mg/kg 的米罗加巴林不会影响旷场试验中的运动活动，提示其不会引起镇静作用。综上所述，这些发现表明米罗加巴林可能是一种治疗口腔颌面手术后 PTTN 的有价值药物，无镇静副作用。
