Scherließ Regina, Bock Simon, Bungert Nicholas, Neustock Anna, Valentin Lena
Department of Pharmaceutics and Biopharmaceutics, Kiel University, Grasweg 9a, 24118 Kiel, KiNSIS Priority Research Area, Kiel University.
Department of Pharmaceutics and Biopharmaceutics, Kiel University, Grasweg 9a, 24118 Kiel, KiNSIS Priority Research Area, Kiel University.
Eur J Pharm Sci. 2022 May 1;172:106158. doi: 10.1016/j.ejps.2022.106158. Epub 2022 Mar 4.
Drug administration by inhalation is a well-established approach to treat respiratory and systemic diseases. To deliver a drug into the lung dry powder inhalation (DPI) is an advantageous, but yet challenging option. A variety of strategies is available for developing DPI formulations. These formulation strategies should address the present disadvantage of insufficient drug delivery and enable therapies in general or to reach new targets (e.g. mucosal vaccination). To increase therapy safety and efficacy scientists challenge the limits of technical feasibility to engineer respiratory medicines. In this review, we provide a concise overview of particle engineering as enabling formulation technique or as an optimisation approach for existing strategies in pulmonary drug delivery. It comprehensively describes different techniques for particle engineering in carrier-based blends for inhalation. This covers considerations on which attributes are beneficial for carriers, followed by methods to modify such attributes or directly manufacture the desired carriers. Furthermore, this work comprises the current state of knowledge on nanocrystal and nanoparticle production as well as other carrier-free technologies and their applications. This review is completed by a glance in the future of carrier engineering using additive manufacturing.
吸入给药是治疗呼吸系统疾病和全身性疾病的一种成熟方法。将药物输送到肺部，干粉吸入器（DPI）是一种有利但仍具有挑战性的选择。开发DPI制剂有多种策略。这些制剂策略应解决目前药物递送不足的缺点，并使一般治疗成为可能或实现新的目标（例如粘膜疫苗接种）。为了提高治疗安全性和有效性，科学家们挑战技术可行性的极限来设计呼吸道药物。在本综述中，我们简要概述了颗粒工程，它作为一种使能制剂技术或作为肺部药物递送现有策略的优化方法。它全面描述了用于吸入的基于载体的混合物中颗粒工程的不同技术。这包括对哪些属性对载体有益的考虑，然后是修改这些属性或直接制造所需载体的方法。此外，这项工作包括纳米晶体和纳米颗粒生产以及其他无载体技术及其应用的当前知识状态。通过展望使用增材制造的载体工程的未来，完成了本综述。
